Evidence map›Paper›PMID 42539622›Full record

ArticleJournal of bone oncology2026

Risk factors and clinical impact of bone pain in patients with multiple myeloma - A prospective interdisciplinary study.

Carlotta Pietsch, Monika Engelhardt, Julian P Maier, Gabriele Ihorst, Hagen Schmal, Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Ralph Wäsch, Georg W Herget

Abstract read
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Article in Journal of bone oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carlotta PietschDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Monika EngelhardtComprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Julian P MaierDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Gabriele IhorstClinical Trials Unit, Medical Clinic, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Hagen SchmalDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Evangelos TerposDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Ioannis Ntanasis-StathopoulosDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Ralph WäschComprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Georg W HergetDepartment of Orthopedics and Trauma Surgery, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bone pain affects up to 80% of patients with multiple myeloma (MM) patients and significantly impairs quality of life (QoL), yet its specific predictors remain poorly characterized. Identifying risk factors is essential for early intervention and personalized treatment. Methods: This prospective, single-center study included 352 patients. Bone pain was recorded using a standardized questionnaire. Multivariate logistic regression with stepwise selection was used to identify independent predictors of bone pain. QoL and health-related status were assessed on a 7-point scale and compared using the Wilcoxon two-sample test. Results: Bone pain was reported by 184 patients (52%). Independent predictors of bone pain were osteolytic lesions with fracture risk (OR 3.06, 95% CI 1.46-6.40, Conclusions: Osteolytic lesions with fracture risk and pre-existing orthopedic conditions independently predict bone pain in patients with MM. These findings highlight the different etiology and the overlap between orthopedic and oncological conditions. Interdisciplinary management is essential to distinguish MM-caused pain from degenerative pain and optimize individualized care.

Indexed as

Bone painMultiple myelomaMyeloma bone diseaseOrthopedic conditionOsteolysisPROMs

Identifiers

PMID42539622
PMCPMC13424186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.