ArticleFrontiers in cellular and infection microbiology2026
Twelve-month functional and structural outcomes of
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To characterize twelve-month visual outcomes, structural complications, and retinal pigment epithelium (RPE) dynamics stratified by initial lesion morphology in an iatrogenic, single-center outbreak of Methods: This retrospective longitudinal cohort study included patients from a single-source outbreak. Of 26 eyes in the original cohort, 18 were classified with chorioretinal involvement and 8 with intraretinal or preretinal involvement. After excluding eyes with severe baseline destruction or loss to follow-up, 13 chorioretinal eyes and 8 intraretinal or preretinal eyes completed the twelve-month follow-up. Main outcome measures included best-corrected visual acuity (BCVA), complication rates, the incidence of secondary macular neovascularization (MNV) using optical coherence tomography angiography (OCTA), and longitudinal RPE lesion area changes quantified via optical coherence tomography (OCT). Results: Although both groups experienced functional improvement after treatment, the chorioretinal group had significantly worse final BCVA at twelve months (median 0.80 versus 0.20 LogMAR; Conclusions: Initial chorioretinal involvement was associated with poorer visual recovery and a markedly higher incidence of secondary MNV. The early expansion of RPE lesions alongside visual improvement likely reflects tissue remodeling and may be less suggestive of ongoing infection. These findings support routine OCT and OCTA surveillance and timely anti-vascular endothelial growth factor therapy for eyes with chorioretinal involvement.
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