Evidence map›Paper›PMID 42539370›Full record

ArticleNeurotrauma reports

Proteomic Changes of Neurodegenerative and Inflammatory Plasma Biomarkers Following Traumatic Brain Injury.

Sabrina Abbruzzese, Ronit Patel, Alexa E Walter, Cillian E Lynch, Danielle K Sandsmark, Douglas H Smith, Andrea L C Schneider, Ramon Diaz-Arrastia

Abstract read
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In one paragraph

Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabrina AbbruzzeseDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0002-6683-5740
Ronit PatelDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0006-5292-0214
Alexa E WalterDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Cillian E LynchDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Danielle K SandsmarkDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Douglas H SmithDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrea L C SchneiderDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Analytical characterization and validation of blood-biomarkers for monitoring TBI evolutionU01NS131740 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ramon Diaz-Arrastia, Ava M. Puccio · 2024 to 2026
$4.7M
Clinical Validation of Serum Neurofilament Light as a Biomarker of Traumatic Axonal InjuryU01NS114140 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DIAZ-ARRASTIA, RAMON · 2020 to 2025
$3.9M
Establishing Mechanisms Between Traumatic Brain Injury and Dementia Using Epidemiology, Clinical Studies, Blood-Based Biomarkers, and Neuroimaging BiomarkersK23NS123340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Andrea Lauren Christman Schneider · 2022 to 2026
$1.1M
NINDS NIH HHS K23 NS123340NINDS NIH HHS U01 NS114140NINDS NIH HHS U01 NS131740
6 · The paper itself

Abstract

Our objective was to determine if relative concentrations of neurodegenerative and inflammatory biomarkers differed between traumatic brain injury (TBI) and age-matched controls. Among individuals with TBI, we sought to evaluate differences in biomarker expression by injury severity, investigate changes in biomarkers over the first 2 weeks post-injury, and assess associations with functional outcome. Plasma samples from 126 individuals with TBI were collected at day 1 (

Indexed as

biomarkersinflammationneurodegenerationtraumatic brain injury

Identifiers

PMID42539370
PMCPMC13422615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.