Evidence map›Paper›PMID 42539332›Full record

ArticlebioRxiv : the preprint server for biology2026

Conformational dynamics of exopolysaccharides underlie biofilm matrix mechanics in

Kee-Myoung Nam, Nathan Fowler, Rajan Kandel, Yongqi Zhu, Yuchu Liu, Yi-Jhen Lai, Muhammad Faheem Hassan, Emma Gerace, Merrill Asp, Rich Olson and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kee-Myoung NamDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0000-0002-3594-6141
Nathan FowlerDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Rajan KandelComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Yongqi ZhuDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT, USA.
Yuchu LiuDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Yi-Jhen LaiPolymer Program, Institute of Materials Science, University of Connecticut-Storrs, Storrs, CT, USA.
Muhammad Faheem HassanDepartment of Chemical and Biomolecular Engineering, University of Connecticut-Storrs, Storrs, CT, USA.
Emma GeraceDepartment of Molecular Biology and Biochemistry, Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.
Merrill AspDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Rich OlsonDepartment of Molecular Biology and Biochemistry, Molecular Biophysics Program, Wesleyan University, Middletown, CT, USA.ORCID 0000-0002-5432-206X
Ying LiDepartment of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Mu-Ping NiehPolymer Program, Institute of Materials Science, University of Connecticut-Storrs, Storrs, CT, USA.
Mingjiang ZhongDepartment of Chemical and Environmental Engineering, Yale University, New Haven, CT, USA.
Robert J WoodsComplex Carbohydrate Research Center, University of Georgia, Athens, GA, USA.
Alexis MoreauDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.
Jing YanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
Tracking single-cell gene expression heterogeneity and its consequences in bacterial biofilmsDP2GM146253 · NIGMS · YALE UNIVERSITY · PI YAN, JING · 2021 to 2024
$2.5M
NIGMS NIH HHS DP2 GM146253NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

Polysaccharides remain the least understood biomacromolecules, particularly in terms of the relationship between their chemical structure and physical properties. On the other hand, polysaccharides often serve as the main structural components in biofilms: surface-attached aggregates of bacterial cells encased within a mechanically resilient extracellular matrix. The large chemical space explored by bacteria within biofilms provides excellent opportunities to establish the structure-function relationship for polysaccharides. In this paper, we systematically characterize various polymer properties of Vibrio polysaccharide (VPS), the major exopolysaccharide in biofilms formed by

Identifiers

PMID42539332
PMCPMC13420445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.