ArticleNeurotrauma reports
Salivary MicroRNAs as Biomarkers for Identification and Prognosis in Adolescents Following Concussion.
Article in Neurotrauma reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MicroRNAs (miRNAs), which are small noncoding RNAs involved in gene regulation that can be measured reliably in saliva, have emerged as promising biomarker candidates for identifying concussion. However, research thus far is limited, and the role of miRNAs in prognosis following concussion in adolescents remains largely unexplored. This case-cohort study investigated whether salivary miRNAs collected within 10 days of injury could identify concussed adolescents from age- and sex-matched, healthy, uninjured controls, and predict symptom burden at 3-weeks post injury. Saliva samples were collected from 58 concussed adolescents (mean age [SD] = 15.4 [1.6] years; 25 females) within 10 days of injury, and 35 age- and sex-matched, healthy, uninjured controls. Using a neurodegenerative panel of 798 miRNAs, we applied feature selection to identify miRNAs that best identified concussed from healthy, uninjured adolescents. Additional analysis investigated whether these miRNAs were able to predict concussion symptom burden 3-weeks post injury. Results indicated that two miRNAs were significantly upregulated in concussed participants: (1) hsa-miR-26a-5p (F = 8.2,
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