Evidence map›Paper›PMID 42539266›Full record

ArticlebioRxiv : the preprint server for biology2026

Steady-state water exchange in neural tissue is primarily passive and through the phospholipid bilayer.

Nathan H Williamson, Rea Ravin, Teddy X Cai, Julian A Rey, Peter J Basser

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathan H WilliamsonEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-0221-9121
Rea RavinEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0007-2543-4007
Teddy X CaiEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6118-100X
Julian A ReyEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Peter J BasserEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-4795-6088

Funding

Postdoctoral Research Associate Training Program (PRAT)ZIEGM000002 · NIGMS · NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES · PI NELSON, SHAKIRA · 2009 to 2025
$31.7M
Quantitative Imaging of Water Transport and Relaxation Processes in the Brain and in Other Soft TissuesZIAHD008971 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BASSER, PETER J. · 2018 to 2025
$10.5M
Transport Processes and Nervous System FunctionZIAHD008972 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BASSER, PETER J. · 2018 to 2025
$5.9M
Multiscale brain tissue finite element mechanical modeling to infer brain microstructural properties from magnetic resonance elastographyFI2GM150429 · NIGMS · U.S. NATIONAL INST/CHILD HLTH/HUMAN DEV · PI REY, JULIAN ALEJANDRO · 2023 to 2023
–
Intramural NIH HHS ZIA HD008971Intramural NIH HHS ZIA HD008972Intramural NIH HHS ZIE GM000002NIGMS NIH HHS FI2 GM150429
6 · The paper itself

Abstract

Water molecules exchange incessantly across cell membranes and between intracellular compartments, but the dominant steady-state transport pathways, and whether they are active or passive, remain unclear. Low-field, high-gradient diffusion exchange spectroscopy (DEXSY) nuclear magnetic resonance (NMR) measurements on viable

Indexed as

gray matterHomeostasismembrane permeabilityporous mediatissue microstructure

Identifiers

PMID42539266
PMCPMC13419834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.