Evidence map›Paper›PMID 42539256›Full record

ArticlebioRxiv : the preprint server for biology2026

ProteinDock: A physics-informed layer to improve protein-protein docking reliability.

Gowrish Rajagopal, Søren C Spina, Joseph S Bailey, Blaise R Kimmel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gowrish RajagopalDepartment of Computer Science and Engineering, The Ohio State University, Columbus, OH, 43210, United States.
Søren C SpinaDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, United States.
Joseph S BaileyDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, United States.
Blaise R KimmelDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, United States.ORCID 0000-0002-9582-9887

Funding

Targeted Prodrug Cytokines for Metastatic Breast Cancer ImmunotherapyR21CA312456 · NCI · OHIO STATE UNIVERSITY · PI Blaise Russel Kimmel · 2026 to 2026
$385k
NCI NIH HHS R21 CA312456
6 · The paper itself

Abstract

Computational modeling provides geometric insight into protein-protein interactions without requiring the resources of experimentation. However, reliability can be hindered when modeling proteins with distinctive features, such as antibodies, that use flexible, polar-rich loops to bind antigens. We developed

Indexed as

Antibody-AntigenProtein-protein dockingRosettaStructural Prediction

Identifiers

PMID42539256
PMCPMC13420419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.