Evidence map›Paper›PMID 42539252›Full record

ArticlebioRxiv : the preprint server for biology2026

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.

Clare M Wieland, Shannon E Wright, Sydney Willey, Ishita Purwar, Samantha J Grudzien, Amy Krans, Erinn Laimon, Melissa J Asher, Adrian Isaacs, Amanda L Garner and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Clare M WielandDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Shannon E WrightDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Sydney WilleyDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Ishita PurwarDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Samantha J GrudzienDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Amy KransDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Erinn LaimonDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Melissa J AsherDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.
Adrian IsaacsUK Dementia Research Institute at UCL, London, UK.
Amanda L GarnerDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI, 48109 USA.
Peter K ToddDepartment of Neurology, University of Michigan, Ann Arbor, MI, 48109 USA.ORCID 0000-0003-4781-6376

Funding

The FMR1 CGG repeat as functional element and therapeutic target in Fragile X associated disordersP50HD104463 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI TODD, PETER K · 2020 to 2024
$9.0M
Hexanucleotide repeat translation in ALS and Frontotemporal DementiaR01NS099280 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter K Todd · 2016 to 2026
$4.9M
CGG repeat associated translation in Fragile X-associated Tremor/Ataxia Syndrome-Diversity SupplementR01NS086810 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODD, PETER K · 2014 to 2024
$4.1M
Training Program in Translational ResearchT32GM141840 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREW P LIEBERMAN, Zaneta Nikolovska-Coleska · 2021 to 2026
$2.0M
Chemical Biology Approaches for Investigating RNA-Protein InteractionsR35GM153185 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Amanda Garner · 2024 to 2026
$1.6M
CGG repeat associated translation in Fragile X gene function and diseaseF31NS113513 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WRIGHT, SHANNON · 2020 to 2022
$84k
BLRD VA I01 BX004842NICHD NIH HHS P50 HD104463NIGMS NIH HHS R35 GM153185NIGMS NIH HHS T32 GM141840NINDS NIH HHS F31 NS113513NINDS NIH HHS R01 NS086810NINDS NIH HHS R01 NS099280
6 · The paper itself

Abstract

Intronic GGGGCC repeat expansions in

Identifiers

PMID42539252
PMCPMC13419757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.