Evidence map›Paper›PMID 42539239›Full record

ArticlebioRxiv : the preprint server for biology2026

A multimodal interrogation of Broca's area in the pediatric and adult human brain.

Juan Moriano, Tanzila Mukhtar, Jimmy Tsz Hang Lee, Fani Memi, Jonathan Augustin, Rachel Leonard, Joseph Asfouri, I-Ling Lu, Clara Siebert, Jennifer Ja-Yoon Choi and 26 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Juan MorianoDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0001-6781-340X
Tanzila MukhtarDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0001-9646-8940
Jimmy Tsz Hang LeeWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID 0000-0003-1208-8356
Fani MemiWellcome Sanger Institute, Hinxton, Cambridge, UK.
Jonathan AugustinDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0002-3302-4426
Rachel LeonardDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Joseph AsfouriDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
I-Ling LuEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Clara SiebertDepartment of Neurology, University of California, San Francisco, CA, USA.
Jennifer Ja-Yoon ChoiDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Guolong ZuoDepartment of Neurology, University of California, San Francisco, CA, USA.
Yinshui ChangWellcome Sanger Institute, Hinxton, Cambridge, UK.
Stanislaw MakarchukWellcome Sanger Institute, Hinxton, Cambridge, UK.
Elina JinWellcome Sanger Institute, Hinxton, Cambridge, UK.
Martin PreteWellcome Sanger Institute, Hinxton, Cambridge, UK.
Shaohui WangDepartment of Neurology, University of California, San Francisco, CA, USA.
Qiuli BiDepartment of Neurology, University of California, San Francisco, CA, USA.
Yuhan HaoDepartment of Neurological Surgery, University of California, San Francisco, CA, USA.
Liz TuckWellcome Sanger Institute, Hinxton, Cambridge, UK.
Katy TudorWellcome Sanger Institute, Hinxton, Cambridge, UK.
Vanessa B PereiraWellcome Sanger Institute, Hinxton, Cambridge, UK.
Hon Man ChanWellcome Sanger Institute, Hinxton, Cambridge, UK.
Jasmine HalliwellWellcome Sanger Institute, Hinxton, Cambridge, UK.
Benjamin RumneyWellcome Sanger Institute, Hinxton, Cambridge, UK.
Holly AndersonWellcome Sanger Institute, Hinxton, Cambridge, UK.
Arren RamseyDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Fabian TheisInstitute of Computational Biology, Helmholtz Munich, Munich, Germany.
Mercedes ParedesDepartment of Neurology, University of California, San Francisco, CA, USA.
Xianhua PiaoEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Elizabeth E CrouchEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Arturo Alvarez-BuyllaEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
David RowitchEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.
Eric J HuangDepartment of Pathology, University of California San Francisco, San Francisco, CA, USA.
Tomasz J NowakowskiEli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA.ORCID 0000-0003-2345-4964
Omer Ali BayraktarWellcome Sanger Institute, Hinxton, Cambridge, UK.ORCID 0000-0001-6055-277X
Arnold KriegsteinDepartment of Neurology, University of California, San Francisco, CA, USA.ORCID 0000-0001-5742-2990

Funding

Regulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALVAREZ-BUYLLA, ARTURO · 2014 to 2024
$12.6M
NINDS NIH HHS P01 NS083513Wellcome Trust
6 · The paper itself

Abstract

Language is a defining trait of our species, and disruptions in language acquisition can have profound consequences to the individuals affected. Uncovering the neurodevelopmental basis of this complex trait requires detailed molecular and cellular insights into the neocortical areas that support linguistic abilities. Here we performed joint gene expression and chromatin accessibility profiling at single-nucleus resolution (10x Genomics Single cell Multiome) and spatial transcriptomic profiling (Xenium high-plex

Identifiers

PMID42539239
PMCPMC13419821

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.