Evidence map›Paper›PMID 42539217›Full record

ArticlebioRxiv : the preprint server for biology2026

Functional Data Analysis of Spatial Clustering Identifies Prognostic T Cell Patterns in Ovarian Cancer.

Chase J Sakitis, Daisy Liao, Brett M Reid, Mary K Townsend, Joellen M Schildkraut, Andrew B Lawson, Shelley S Tworoger, Kathryn L Terry, Lauren C Peres, Julia Wrobel and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chase J SakitisDivision of Health Services & Outcomes Research, Children's Mercy, Kansas City, MO, USA.ORCID 0009-0007-5651-371X
Daisy LiaoDepartment of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0009-0006-3449-475X
Brett M ReidDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL.ORCID 0000-0001-9702-257X
Mary K TownsendDivision of Oncological Sciences and the Knight Cancer Institute, Oregon Health and Science University, Portland, OR.ORCID 0000-0002-9954-4846
Joellen M SchildkrautDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0000-0002-0990-9339
Andrew B LawsonDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC.ORCID 0000-0002-8751-4551
Shelley S TworogerDivision of Oncological Sciences and the Knight Cancer Institute, Oregon Health and Science University, Portland, OR.ORCID 0000-0002-6986-7046
Kathryn L TerryDepartment of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.ORCID 0009-0002-5848-4661
Lauren C PeresDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL.ORCID 0000-0002-6620-8600
Julia WrobelDepartment of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0000-0001-6783-1421
Alex C SoupirDepartment of Biostatistics and Bioinformatics, Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, FL.ORCID 0000-0003-1251-9179
Brooke L FridleyDivision of Health Services & Outcomes Research, Children's Mercy, Kansas City, MO, USA.ORCID 0000-0001-7739-7956

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Epidemiology of Ovarian Cancer in African-American WomenR01CA142081 · NCI · UNIVERSITY OF VIRGINIA · PI SCHILDKRAUT, JOELLEN M. · 2010 to 2015
$10.6M
Ovarian Cancer Survival in African-American WomenR01CA237318 · NCI · EMORY UNIVERSITY · PI LAWSON, ANDREW B., SCHILDKRAUT, JOELLEN M. · 2020 to 2024
$5.9M
NRSA Training CoreTL1TR002368 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jennifer Lynn Goldman, NICOLE L NOLLEN · 2017 to 2026
$4.0M
Spatial and Bayesian modeling methods for assessment of the tumor immune microenvironment and survival of women with ovarian cancerR01CA279065 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Brooke L Fridley, Lauren Cole Peres · 2023 to 2026
$2.2M
The Role of Inflammation in the Racial Disparities in Ovarian Cancer SurvivalR00CA218681 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI PERES, LAUREN COLE · 2018 to 2020
$722k
NCATS NIH HHS TL1 TR002368NCI NIH HHS P01 CA087969NCI NIH HHS R00 CA218681NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA237318NCI NIH HHS R01 CA279065NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Spatial proteomic imaging technologies enable the simultaneous assessment of immune cell abundance and spatial organization within the tumor microenvironment. Spatial clustering is commonly summarized using measures such as Ripley's

Indexed as

functional data analysisovarian cancerspatial proteomicssurvivaltumor microenvironment

Identifiers

PMID42539217
PMCPMC13419803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.