Evidence map›Paper›PMID 42539209›Full record

ArticlebioRxiv : the preprint server for biology2026

TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism.

Ryo Hagimori, Michael Landowski, Siyu Song, Purnima Gogoi, Richard S Brush, Sarah M Bonvicino, Greg Barrett-Wilt, Sakae Ikeda, Ken-Ichi Yamada, Chi-Liang Eric Yen and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryo HagimoriDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Michael LandowskiDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Siyu SongDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Purnima GogoiDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Richard S BrushDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Sarah M BonvicinoDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Greg Barrett-WiltMass Spectrometry Core Facility, Biotechnology Center, University of Wisconsin-Madison, Madison, WI, USA.
Sakae IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Ken-Ichi YamadaDepartment of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Chi-Liang Eric YenDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Tetsuya TakimotoOncology Innovation Center, Fujita Health University, Toyoake, Aichi, Japan.
Martin-Paul AgbagaDepartment of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Akihiro IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Molecular Genetics of Age-Dependent Retinal DegenerationR01EY022086 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2012 to 2026
$6.1M
Essential Role of Very Long Chain Fatty Acids in Retinal FunctionR01EY030513 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AGBAGA, MARTIN-PAUL · 2019 to 2023
$1.8M
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY022086NEI NIH HHS R01 EY030513NIH HHS S10 OD023526
6 · The paper itself

Abstract

TMEM135 has been implicated in lipid metabolism, but its role in regulating hepatic lipid homeostasis remains unclear. Here, we investigated how TMEM135 affects hepatic lipid metabolism using

Identifiers

PMID42539209
PMCPMC13419758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.