Evidence map›Paper›PMID 42539183›Full record

ArticlebioRxiv : the preprint server for biology2026

Direct measurement of

Eric M Ndombi, John Oguso, Peter Olilah, Churchill Orao, Brian Otieno, Madison Morales, Winka Le Clec'h, Frédéric D Chevalier, Timothy Anderson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric M NdombiDepartment of Medical Microbiology & Parasitology, Kenyatta University, Nairobi, Kenya.ORCID 0000-0002-7809-4452
John OgusoKenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
Peter OlilahKenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
Churchill OraoKenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
Brian OtienoKenya Medical Research Institute-Centre for Global Health Research (KEMRI-CGHR), Kisumu, Kenya.
Madison MoralesSouthwest Research Institute, San Antonio, Texas, USA.
Winka Le Clec'hTexas Biomedical Research Institute, Host-Pathogen Interactions, San Antonio, Texas, USA.
Frédéric D ChevalierTexas Biomedical Research Institute, Host-Pathogen Interactions, San Antonio, Texas, USA.ORCID 0000-0003-2611-8106
Timothy AndersonTexas Biomedical Research Institute, Disease Intervention and Prevention, San Antonio, Texas, USA.ORCID 0000-0002-0191-0204

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Genetic Basis of Praziquantel ResistanceR01AI123434 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J, LOVERDE, PHILIP T · 2016 to 2020
$3.5M
Genetic analysis of cercarial release in schistosomesR01AI133749 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2017 to 2021
$2.5M
Characterisation of drug resistance in field-collected schistosomesR01AI160433 · NIAID · KENYATTA UNIVERSITY · PI NDOMBI, ERIC MAKUTO · 2021 to 2025
$786k
Role of the microbiome of the schistosome snail hostR21AI171601 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI CHEVALIER, FREDERIC DAVID, LE CLEC'H, WINKA MAI · 2022 to 2023
$545k
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
NCRR NIH HHS C06 RR013556NIAID NIH HHS R01 AI123434NIAID NIH HHS R01 AI133749NIAID NIH HHS R01 AI160433NIAID NIH HHS R21 AI171601NIH HHS P51 OD011133
6 · The paper itself

Abstract

Large-scale treatment with praziquantel (PZQ) monotherapy is used to control schistosomiasis, leading to concerns about the emergence of PZQ-resistance. In Western Kenya, schistosome-infected patients frequently remain egg-positive following PZQ treatment, and several "hotspot" villages have been observed where transmission remains high, despite annual mass PZQ treatments. This project asks (i) whether PZQ-resistant parasites are found in Western Kenya and (ii) whether "hotspot" villages can be explained by a higher prevalence of PZQ-resistant parasites. We established a simple platform for directly assaying worm motility following

Indexed as

drug resistancemovement assayPraziquantelSchistosoma mansoni

Identifiers

PMID42539183
PMCPMC13419779

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.