Evidence map›Paper›PMID 42539178›Full record

ArticlebioRxiv : the preprint server for biology2026

Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors.

Neil K Savalia, Ling-Xiao Shao, Cory A Knox, Amelia D Gilbert, Quan Jiang, Alex C Kwan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Neil K SavaliaMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-2262-4466
Ling-Xiao ShaoMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0006-9503-1230
Cory A KnoxMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0006-4376-2429
Amelia D GilbertMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0008-5728-2674
Quan JiangMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-8201-6417
Alex C KwanMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-2169-1667

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Cellular basis of psilocybin actions in frontal cortexR01MH128217 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2022 to 2026
$2.9M
Role of cortical GABAergic interneurons in psychedelic drug actionR01MH137047 · NIMH · CORNELL UNIVERSITY · PI CHUN-HAY ALEX KWAN · 2024 to 2026
$1.9M
Acquisition of an automated phase and fluorescence microscope for Cornell BRC Imaging FacilityS10OD032251 · OD · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2022 to 2022
$229k
Leveraging Rapid-Acting Antidepressants for Personalized ResponseF30MH129085 · NIMH · YALE UNIVERSITY · PI SAVALIA, NEIL · 2021 to 2023
$115k
The inhibitory mechanism underlying psychedelic disruption of visual processingF31EY038625 · NEI · CORNELL UNIVERSITY · PI Cory Knox · 2026 to 2026
$47k
NEI NIH HHS F31 EY038625NIGMS NIH HHS T32 GM007205NIH HHS S10 OD032251NIMH NIH HHS F30 MH129085NIMH NIH HHS R01 MH128217NIMH NIH HHS R01 MH137047
6 · The paper itself

Abstract

How psychedelics act on cortical dendrites to produce long-lasting structural plasticity remains poorly understood. Here, we characterize the effects of psilocybin on dendritic calcium dynamics in pyramidal tract neurons of the mouse medial frontal cortex. Psilocybin transiently increases calcium event rates in apical dendritic tufts over a time course that parallels the drug's pharmacokinetics in the brain. This acute effect is brain state-dependent, occurring selectively during quiet wakefulness, and was abolished by cell type-specific deletion of the 5-HT

Indexed as

calcium signalingdendritic spinesexcitatory neuronsfrontal cortexPsilocybinpyramidal cellsstructural plasticity

Identifiers

PMID42539178
PMCPMC13419809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.