In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Anastasia TsivesDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine; New Haven, CT, USA.
Shih Ming HuangDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-5070-1732 Zhanat KoshenovDepartment of Biochemistry & Biophysics, Weill Cornell Medicine, New York, NY, USA.
Raghabendra AdhikariHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.
Aaron D WolfeDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine; New Haven, CT, USA.ORCID 0000-0002-4926-5064 Ian J GonzalezDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine; New Haven, CT, USA.
Daniel FelicianoHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.
Matthew J MerrinsDepartment of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-1599-9227 Daniel A Colón-RamosDepartment of Neuroscience and Department of Cell Biology, Yale University School of Medicine; New Haven, CT, USA.ORCID 0000-0003-0223-7717 Timothy A BrownHoward Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA.
Funding
Physiology of Single Synaptic CNS TerminalsR01NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Timothy Aidan Ryan · 1998 to 2026
$6.8MExamination of the cell biology of the synapse and behaviorR35NS132156 · NINDS · YALE UNIVERSITY · PI DANIEL A COLON-RAMOS · 2023 to 2026
$4.6MPhysiology of Single Synaptic CNS TerminalsR37NS036942 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI RYAN, TIMOTHY AIDAN · 2016 to 2022
$3.5MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4MMetabolic Functions of Pyruvate Kinase M2 in Pancreatic Beta CellsR01DK113103 · NIDDK · YALE UNIVERSITY · PI Matthew J. Merrins · 2017 to 2026
$3.3MMetabolic signaling of the beta cell primary ciliumR01DK140365 · NIDDK · YALE UNIVERSITY · PI Jing Wang Hughes, Matthew J. Merrins · 2024 to 2026
$1.9MMechanisms of islet compensation for β-cell mass deficiency in diabetesR01DK139640 · NIDDK · YALE UNIVERSITY · PI Seung K Kim, Matthew J. Merrins · 2025 to 2026
$1.5MAdaptive glycolysis as a regulator of neuronal function and declineK99AG083129 · NIA · YALE UNIVERSITY · PI WOLFE, AARON · 2023 to 2024
$252kNIA NIH HHS K99 AG083129NIDDK NIH HHS R01 DK113103NIDDK NIH HHS R01 DK127637NIDDK NIH HHS R01 DK139640NIDDK NIH HHS R01 DK140365NINDS NIH HHS R01 NS036942NINDS NIH HHS R35 NS132156NINDS NIH HHS R37 NS036942
6 · The paper itselfAbstract
Glucose-6-phosphate (G6P) is a key intermediate in multiple energetic and anabolic pathways, and quantifying its dynamics is essential for understanding cellular physiology. We have previously developed a syndicate of intensity-based, genetically encoded sensors based on the insertion of circularly permuted GFP into a Venus-flytrap-like analyte-binding protein. Here we use the same approach to develop an intensity-based G6P Sensing Fluorescent Reporter (iG6PSnFR). We present two variants: a G6P-activated sensor that increases fluorescence and a G6P-inactivated sensor that decreases fluorescence. We validate performance across progressively more complex preparations, including purified protein in vitro, immortalized and primary neuronal cultures, isolated pancreatic islets, in an intravital liver model, and finally in vivo in
Identifiers
PMID42539160
PMCPMC13419708
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