ArticlebioRxiv : the preprint server for biology2026
Parabrachial bombesin receptor subtype 3 neurons facilitate heat hypersensitivity in persistent pain.
Heather N Allen, Erick J Rodríguez-Palma, Tyler S Nelson, Naomi K Grabus, Nia A Dufeal, Rajesh Khanna
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors.
Heather N AllenDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0003-0771-1959 Erick J Rodríguez-PalmaDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Tyler S NelsonDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0002-6675-4820 Naomi K GrabusDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Nia A DufealDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.
Rajesh KhannaDepartment of Pharmacology & Therapeutics, McKnight Brain Institute, Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0002-9066-2969 Funding
Validation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingRF1NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2023 to 2023
$2.0MDissecting the Parabrachial Nucleus’s Role in the Development and Maintenance of Neuropathic PainK00NS124190 · NINDS · UNIVERSITY OF FLORIDA · PI Tyler Scott Nelson · 2023 to 2026
$346kNeuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic PainF32NS128392 · NINDS · UNIVERSITY OF FLORIDA · PI ALLEN, HEATHER NOEL · 2023 to 2025
$217kNINDS NIH HHS F32 NS128392NINDS NIH HHS K00 NS124190NINDS NIH HHS RF1 NS131165
6 · The paper itselfAbstract
The parabrachial nucleus (PBN) is a critical hub for pain processing that acts as a switchboard for nociceptive signals, relaying sensory information to forebrain regions that integrate the sensory and affective dimensions of pain. Although the PBN is well established as a key regulator of pain, the remarkable heterogeneity of its neuronal populations has hindered efforts to identify specific cell types responsible for distinct aspects of pain processing. Here, we identify bombesin receptor subtype 3 (
Indexed as
bombesin receptor subtype 3inflammationneuropathicpainparabrachial nucleus
Identifiers
PMID42539134
PMCPMC13419693
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