Evidence map›Paper›PMID 42539110›Full record

ArticlebioRxiv : the preprint server for biology2026

Unmasking Early Renal Fibrosis in Polycystic Kidney Disease Using Noninvasive Precision Molecular MRI of Collagen.

Oluwabukola S Bamishaye, Francis Akinlotan, Jingjuan Qiao, Phillip H Chumley, Farzaneh Dorabadizare, Annye Bennett, Xiu Chen, Roye Ronald, Mandy J Croyle, Khan Hekmatyar and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Oluwabukola S BamishayeDivision of Hematology Oncology and Department of Medicine, University of Alabama Birmingham; Birmingham, AL, 30322, USA.ORCID 0009-0002-0569-8500
Francis AkinlotanDivision of Hematology Oncology and Department of Medicine, University of Alabama Birmingham; Birmingham, AL, 30322, USA.ORCID 0000-0003-0009-808X
Jingjuan QiaoDivision of Hematology Oncology and Department of Medicine, University of Alabama Birmingham; Birmingham, AL, 30322, USA.ORCID 0000-0002-4277-6531
Phillip H ChumleyDivision of Nephrology at the University of Alabama at Birmingham (UAB); Birmingham, AL, 35294, USA and Department of Veterans Affairs Medical Center, Birmingham, AL, 35233, USA.ORCID 0009-0007-3039-8979
Farzaneh DorabadizareCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University; Atlanta, GA, 30303, USA.ORCID 0009-0004-2142-8812
Annye BennettSmall Animal Imaging Shared Facility, O'Neal Comprehensive Cancer Center, 1700 University Blvd, Birmingham, AL, 35233, USA.
Xiu ChenDivision of Hematology Oncology and Department of Medicine, University of Alabama Birmingham; Birmingham, AL, 30322, USA.
Roye RonaldDivision of Nephrology at the University of Alabama at Birmingham (UAB); Birmingham, AL, 35294, USA and Department of Veterans Affairs Medical Center, Birmingham, AL, 35233, USA.
Mandy J CroyleDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Khan HekmatyarCenter for Diagnostics and Therapeutics, Advanced Translational Imaging Facility, Department of Chemistry, Georgia State University; Atlanta, GA, 30303, USA.ORCID 0009-0003-7275-9702
Alton B FarrisPathology Department, Emory University School of Medicine; Atlanta, GA, 30322, USA.ORCID 0000-0001-5534-7763
Anna G SoraceSmall Animal Imaging Shared Facility, O'Neal Comprehensive Cancer Center, 1700 University Blvd, Birmingham, AL, 35233, USA.ORCID 0000-0002-3640-3966
Harrison KimComprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, USA.ORCID 0000-0002-9126-1964
Jian-Xiong WangDepartment of Radiology, University of Alabama Birmingham; Birmingham, AL, 30322, USA.ORCID 0000-0002-4043-8408
Hans E GrossniklausEye Center, Emory University School of Medicine; Atlanta, GA 30322, USA.ORCID 0000-0003-0178-9712
Bradley K YoderDepartment of Cell, Development, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-0247-1944
Michal MrugDivision of Nephrology at the University of Alabama at Birmingham (UAB); Birmingham, AL, 35294, USA and Department of Veterans Affairs Medical Center, Birmingham, AL, 35233, USA.ORCID 0000-0001-8981-1843
Jenny J YangDivision of Hematology Oncology and Department of Medicine, University of Alabama Birmingham; Birmingham, AL, 30322, USA.ORCID 0000-0002-2310-7658

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Therapeutic Development and Screening ResourceU54DK126087 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI John M Parant · 2020 to 2026
$6.7M
Injury Response Mediated Pathogenesis in Renal CiliopathiesR01DK115752 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Bradley K. Yoder · 2018 to 2026
$4.0M
Noninvasive Contrast Enhanced Early Detection of Melanoma Liver MetastasisR42CA183376 · NCI · INLIGHTA BIOSCIENCES, LLC · PI YANG, JENNY J. · 2017 to 2019
$2.0M
Multi-color Mapping of Cancer Molecular Signatures and Tumor microenvironmentR33CA235319 · NCI · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2019 to 2021
$1.3M
Major upgrade for UAB Bruker BioSpec preclinical 9.4T MRIS10OD028498 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SORACE, ANNA C · 2020 to 2020
$601k
Translational Research by 3T Molecular ImagingS10OD027045 · OD · GEORGIA STATE UNIVERSITY · PI YANG, JENNY J. · 2019 to 2019
$600k
NCI NIH HHS P30 CA013148NCI NIH HHS R33 CA235319NCI NIH HHS R42 CA183376NIDDK NIH HHS R01 DK115752NIDDK NIH HHS U54 DK126087NIH HHS S10 OD027045NIH HHS S10 OD028498
6 · The paper itself

Abstract

Fibrotic remodeling of extracellular matrix is a central driver of autosomal dominant polycystic kidney disease (ADPKD) progression since early stages of the disease. Unfortunately, it cannot be assessed with currently available methodologies before irreversible structural and functional decline, creating a diagnostic blind spot that hinders accurate early risk stratification and management. Here, we report the development of Gd-hProCA32.Collagen, a collagen -targeted protein MRI contrast agent that enables precision molecular MRI (pMRI) of early fibrosis by directly imaging collagen type I deposition

Indexed as

ADPKDchronic kidney diseasecollagen-targeted MRImolecular imagingRenal fibrosis

Identifiers

PMID42539110
PMCPMC13419732

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.