Evidence map›Paper›PMID 42539085›Full record

ArticleArXiv2026

Review of oxygen measurement and relevance to the mechanisms of FLASH radiotherapy.

Brian W Pogue, David I Hunter, Corbin Narita, William S Thomas, Xu Cao, Harold M Swartz

Abstract readPreprint
In one paragraph

Article in ArXiv, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian W PogueThayer School of Engineering at Dartmouth, Hanover, NH, USA 03755.
David I HunterThayer School of Engineering at Dartmouth, Hanover, NH, USA 03755.
Corbin NaritaThayer School of Engineering at Dartmouth, Hanover, NH, USA 03755.
William S ThomasDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705.
Xu CaoThayer School of Engineering at Dartmouth, Hanover, NH, USA 03755.
Harold M SwartzThayer School of Engineering at Dartmouth, Hanover, NH, USA 03755.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Optimization of MeV FLASH radiotherapy for normal tissue preservationU01CA260446 · NCI · DARTMOUTH COLLEGE · PI David J. Gladstone, Jack Hoopes · 2022 to 2026
$3.1M
Oxygen Dynamics in FLASH RadiotherapyR01CA271330 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Brian William Pogue, Sergei Vinogradov · 2023 to 2026
$2.1M
Cherenkov Excited Luminescence Metabolic Sensing (CELMS)R01EB033877 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Brian William Pogue, Sergei Vinogradov · 2024 to 2026
$1.7M
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA271330NCI NIH HHS U01 CA260446NIBIB NIH HHS R01 EB033877
6 · The paper itself

Abstract

FLASH radiotherapy (FLASH-RT) is the phenomenon of relative sparing of normal tissue when ultra-high dose rates (UHDR) are used compared with conventional dose rates (CDR) as clinically used. Despite extensive investigation, the underlying mechanisms remain unexplained. Among the proposed hypotheses, tissue oxygen has consistently been a central theme because oxygen is the most dominant factor known to modulate radiation-induced damage. The factors implicated in FLASH sparing include the baseline partial pressure of oxygen (pO

Identifiers

PMID42539085
PMCPMC13419626

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.