Evidence map›Paper›PMID 42539073›Full record

ArticlemedRxiv : the preprint server for health sciences2026

The Role of Parenting in Mitigating Epigenetic Cardiometabolic Risk in a Sample of Predominantly Latino Preschoolers.

Adamari López, Sarah M Merrill, Anne K Bozack, Andres Cardenas, Jonathan S Comer, Daniel M Bagner, April Highlander, Justin Parent

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adamari LópezDepartment of Psychology, University of Rhode Island, Kingston, RI, USA.ORCID 0009-0005-8288-726X
Sarah M MerrillDepartment of Psychology, University of Massachusetts, Lowell, MA, USA.
Anne K BozackDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Andres CardenasDepartment of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Jonathan S ComerDepartment of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA.
Daniel M BagnerDepartment of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA.
April HighlanderDepartment of Psychology, University of Rhode Island, Kingston, RI, USA.
Justin ParentDepartment of Psychology, University of Rhode Island, Kingston, RI, USA.

Funding

Internet Treatment for Behavior Problems in Preschoolers with Developmental DelayR01HD084497 · NICHD · FLORIDA INTERNATIONAL UNIVERSITY · PI BAGNER, DANIEL MARC, COMER, JONATHAN S · 2015 to 2019
$2.5M
Epigenomic mechanisms of risk and resilience: The role of parentingR01MD015401 · NIMHD · UNIVERSITY OF RHODE ISLAND · PI PARENT, JUSTIN · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD084497NIMHD NIH HHS R01 MD015401
6 · The paper itself

Abstract

Background: Childhood obesity is a prevalent public health concern, particularly among children from marginalized backgrounds. Epigenomic mechanisms, including DNA methylation (DNAm), offer insight into the biological embedding of metabolic risk, yet protective family-level factors remain understudied. This study examined whether participation in a positive parenting intervention was associated with reduced epigenetic cardiometabolic risk among preschool-aged children. Methods: Participants were 74 children ( Results: Children in the intervention group demonstrated significantly lower DNAm BMI at 12 months relative to controls, adjusting for child sex, race and/or ethnicity, and anthropometric BMI. No treatment effect was observed for anthropometric BMI, and DNAm BMI was not associated with anthropometric BMI at 12 months. Although parenting practices improved, they did not mediate intervention effects on DNAm-derived BMI. Conclusions: Parenting interventions may influence biological pathways related to cardiometabolic risk, even before changes in anthropometric outcomes, underscoring the potential of family-centered approaches to promote early metabolic health.

Identifiers

PMID42539073
PMCPMC13419538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.