Evidence map›Paper›PMID 42539053›Full record

ArticleResearch square2026

Standing HA phenotypic breadth shapes H5N1 cross-host potential.

M H M Mubassir, Sachin Subedi, Tanin Rajamand, Mohamed Bakheet, Ludy Registre Carmola, Sihua Peng, Rajan Kandel, Guppy Stott, Robert J Woods, S Mark Tompkins and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M H M MubassirInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.
Sachin SubediInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.ORCID 0000-0002-1145-8880
Tanin RajamandInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.ORCID 0009-0006-1126-4986
Mohamed BakheetCenter for Ecology of Infectious Diseases, University of Georgia, Athens, GA, United States.ORCID 0009-0005-0594-9164
Ludy Registre CarmolaDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Sihua PengCenter for Ecology of Infectious Diseases, University of Georgia, Athens, GA, United States.
Rajan KandelInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.
Guppy StottInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.
Robert J WoodsComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.ORCID 0000-0002-2400-6293
S Mark TompkinsDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.ORCID 0000-0002-1523-5588
Gerardus Josephus BoonsComplex Carbohydrate Research Center, University of Georgia, Athens, GA, United States.ORCID 0000-0003-3111-5954
Justin BahlInstitute of Bioinformatics, University of Georgia, Athens, GA, United States.ORCID 0000-0001-7572-4300

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00018 · NIAID · UNIVERSITY OF GEORGIA · PI TOMPKINS, S. MARK · 2021 to 2025
$21.6M
NIH HHS 75N93021C00018
6 · The paper itself

Abstract

Linking genetic variation to functional phenotype remains a major barrier to assessing the cross-host potential of emerging viruses. Here, we reconstruct the evolution of predicted hemagglutinin (HA) phenotypic traits across ~13,000 highly pathogenic avian influenza A H5N1 clade 2.3.4.4b viruses circulating in North America. The wide geographic spread of avian influenza within North America triggered a wave of broad HA phenotypic diversity that was later refined by the selective sweeps in avian hosts. Following establishment in dairy cattle, however, viral populations exhibited renewed phenotypic diversification in HA, including increased permissiveness for

Identifiers

PMID42539053
PMCPMC13419578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.