ArticleResearch square2026
Quantifying Dexterity and Grip Strength Associations between Age, Cognitive Function (MoCA), and Cerebellar Gray Matter Volume in Healthy Adults across the Adult Lifespan.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Cerebellar Crus I/II gray matter volume (GMV) is a structural marker of cognitive aging, and motor performance (grip strength and manual dexterity) predicts age-related cognitive decline. Whether these motor measures dissociate in their cerebellar and cognitive correlates is unknown. Methods: We examined Pearson partial correlations (age, sex, and race covaried) between grip strength, Nine-Hole Peg Test (9HPT) dexterity, cerebellar Crus I/II GMV, and Montreal Cognitive Assessment (MoCA) subscores in 304 healthy adults aged 20-79 from the University of South Carolina Aging Brain Cohort. GMV was derived from T1-weighted magnetic resonance imaging using the Computational Anatomy Toolbox (CAT12) with the Automated Anatomical Labeling 3 (AAL3) atlas. Results: After false discovery rate (FDR) correction, dominant 9HPT time correlated with MoCA total score ( Conclusion: A double dissociation emerged: Crus II GMV, but not dexterity, independently predicted grip strength, whereas dexterity, but not grip, predicted cognition. Grip strength and dexterity are therefore not interchangeable indices of motor function but map onto distinct substrates: posterior cerebellar integrity tracks maximal-force capacity, whereas fine motor performance indexes memory-related cognitive status independently of cerebellar volume.
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