Evidence map›Paper›PMID 42539049›Full record

ArticleResearch square2026

An Acetylation-Primed SUMOylation Switch Controls RORβ Stability through a p300-SIRT1 Regulatory Axis.

Patrick Griffin, Timothy O'Leary, Denis Shutin, Nadeska Montalvan, Nereida Abad-Yang, Vuong Dang, Dean Edwards, Mi Ra Chang

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrick GriffinThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.ORCID 0000-0002-3404-690X
Timothy O'LearyThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.
Denis ShutinThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.
Nadeska MontalvanSkaggs Graduate School of Chemical and Biological Sciences.
Nereida Abad-YangSkaggs Graduate School of Chemical and Biological Sciences.ORCID 0009-0002-4515-9384
Vuong DangThe Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology.
Dean EdwardsBaylor College of Medicine.
Mi Ra ChangThe Wertheim UF Scripps Research Institute.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
NCI NIH HHS P30 CA125123
6 · The paper itself

Abstract

Retinoic acid receptor-related orphan receptor beta (RORβ) is a transcription factor expressed in the central nervous system, retina, and bone that regulates circadian rhythms, retinal neurogenesis, and inflammatory signaling. Despite these critical functions, the mechanisms governing RORβ stability remain poorly understood. Here, we identify a post-translational regulatory axis in which the lysine acetyltransferase p300 and the NAD

Indexed as

crosslinkingmass spectrometrynuclear receptorsprotein-protein interactionsrapid immunoprecipitation of endogenous proteinsRetinoic acid receptor related orphan receptor-betatranscriptional co-regulatory proteins

Identifiers

PMID42539049
PMCPMC13419597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.