Evidence map›Paper›PMID 42539048›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Treatment-related Cognitive Impairment, Neurovascular Coupling, and Iron Levels in Women with Ovarian Cancer.

Summer Edwards, Quinn Smith, Fan Zhang, Anna Kuan-Celarier, Lei Ding, Doris M Benbrook, Joan Walker, Dee H Wu, Michael Wenger, Han Yuan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Summer EdwardsStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA.
Quinn SmithStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA.
Fan ZhangStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA.
Anna Kuan-CelarierGynecological Oncology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Lei DingStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA.
Doris M BenbrookGynecological Oncology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Joan WalkerGynecological Oncology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Dee H WuRadiological Sciences, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK USA.
Michael WengerDepartment of Psychology, Cellular & Behavioral Neurobiology, University of Oklahoma, Norman, OK, USA.
Han YuanStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK, USA.ORCID 0000-0003-0055-9691

Funding

Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI David W Dyer · 2012 to 2026
$60.2M
Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian CancerP20GM135009 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Javier Antonio Jo · 2022 to 2026
$13.6M
NCI NIH HHS P30 CA225520NIGMS NIH HHS P20 GM103447NIGMS NIH HHS P20 GM135009
6 · The paper itself

Abstract

Chemotherapy is a common treatment for women with ovarian cancer, and many women treated with chemotherapy experience cognitive dysfunction. However, few studies have investigated the mechanisms of chemotherapy-related cognitive impairment in women with ovarian cancer. The goal of this study was to assess the relationships among neurovascular coupling, iron levels and cognitive functions in women with ovarian cancer after first-line chemotherapy. Simultaneous fNIRS and EEG data were collected in women diagnosed with advanced stage ovarian cancer at baseline (N = 13) and after 3-9 rounds of chemotherapy (N = 8). The attentional network task (ANT) was administered for neurocognitive evaluation. Blood iron levels were measured using standard clinical assays. In parallel, similar concurrent fNIRS-EEG data were acquired in a group of 10 healthy participants in a test-retest design. Cognitive performance declined, as indicated by decreases in ANT sub scores after chemotherapy. Blood iron biomarkers indexing oxygen transport also declined and were related to decreases in the ANT sub scores. Both fNIRS and EEG data responses were shown to have excellent reliability in the healthy subjects, while cancer patients showed significant decreases in oxygenated hemoglobin response in fNIRS, despite no changes in EEG responses after chemotherapy. A significant dose relationship was also found in the changes of fNIRS responses. Our data indicate that chemotherapy produced cognitive deficits and decreases in the oxygenated hemoglobin response and that these may be related to reduced oxygen transport capacity. Results also suggest the utility of using fNIRS-EEG to monitor the progression of cognitive impairment and characterize those mechanisms.

Indexed as

chemotherapycognitive impairmentelectroencephalographyfunctional near-infrared spectroscopyneurovascular couplingovarian cancer

Identifiers

PMID42539048
PMCPMC13419556

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.