Evidence map›Paper›PMID 42539046›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Cell composition, transcriptomic, and functional pathway changes in the hippocampus in Alzheimer's disease and overlap with lead (Pb) exposure signatures.

Herong Wang, Evelyn Matei, John Dou, Rachel K Morgan, Justin Colacino, Kelly M Bakulski

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Herong WangEpidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Evelyn MateiMedical School, University of Michigan, Ann Arbor, MI, USA.
John DouEpidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Rachel K MorganEnvironmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Justin ColacinoEnvironmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kelly M BakulskiEpidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9605-6337

Funding

Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Diversity SupplementR01ES028802 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 2018 to 2026
$4.8M
The impact of metals and polygenic risk on multiomics, brain aging, and ADRD outcomesU01AG088407 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Bakulski, Justin Adam Colacino · 2024 to 2026
$4.4M
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type EffectsR01AG072396 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Bakulski, Justin Adam Colacino · 2022 to 2026
$3.7M
NIA NIH HHS P30 AG072931NIA NIH HHS R01 AG072396NIA NIH HHS U01 AG088407NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES028802
6 · The paper itself

Abstract

Background: Lead (Pb) is associated with Alzheimer's disease (AD); however, the relationships between Pb and AD hippocampal transcription remains unclear. We evaluated overlap between Pb-response signatures and cell-type-independent AD transcriptomic signatures. Method: Three toxicology studies (two neuronal cell lines, one mouse hippocampus) provided Pb-response genes. Five human postmortem hippocampal AD case-control transcriptional datasets (n=90 AD, n=106 normal cognition) were cell type deconvoluted and tested with beta regression. Differential gene expression, adjusted for age, sex, and estimated cell-types, were meta-analyzed. Overlapping Pb and AD genes and biological pathways were identified (p Results: Consistent Pb response was observed at 25 genes ( Conclusion: We identified overlapping Pb and AD transcriptomic signatures and pathways, providing molecular context for epidemiologic associations.

Indexed as

Alzheimer’s diseasedementiaLeadneurotoxicologyPb

Identifiers

PMID42539046
PMCPMC13419555

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.