Evidence map›Paper›PMID 42538994›Full record

ArticlebioRxiv : the preprint server for biology2026

Paralogous guanine deaminases acquired from bacteria by horizontal gene transfer promote purine homeostasis in

Sushila Bhattacharya, Lisa Fischer, Evrim Fer, Jennifer Snoozy, Grace N Hagedorn, Marco Herde, Betül Kaçar, Claus-Peter Witte, Kurt Warnhoff

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sushila BhattacharyaCenter for Genetics and Rare Diseases Research, Sanford Research, Sioux Falls, South Dakota, USA.
Lisa FischerDepartment of Molecular Nutrition and Biochemistry of Plants, Leibniz University Hannover, Hannover, Germany.
Evrim FerDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Jennifer SnoozyCenter for Genetics and Rare Diseases Research, Sanford Research, Sioux Falls, South Dakota, USA.
Grace N HagedornCenter for Genetics and Rare Diseases Research, Sanford Research, Sioux Falls, South Dakota, USA.
Marco HerdeDepartment of Molecular Nutrition and Biochemistry of Plants, Leibniz University Hannover, Hannover, Germany.
Betül KaçarDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Claus-Peter WitteDepartment of Molecular Nutrition and Biochemistry of Plants, Leibniz University Hannover, Hannover, Germany.
Kurt WarnhoffCenter for Genetics and Rare Diseases Research, Sanford Research, Sioux Falls, South Dakota, USA.ORCID 0000-0002-9503-0557

Funding

Genetic analyses of molybdenum cofactor biologyR35GM146871 · NIGMS · SANFORD RESEARCH/USD · PI Kurt Warnhoff · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM146871
6 · The paper itself

Abstract

Disruptions in purine metabolism contribute to a range of human diseases, from rare genetic disorders such as Lesch-Nyhan syndrome and xanthinuria to common conditions including gout and cancer. To better understand the metabolic networks that regulate purine homeostasis, we developed a

Identifiers

PMID42538994
PMCPMC13419446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.