Evidence map›Paper›PMID 42538970›Full record

ArticlebioRxiv : the preprint server for biology2026

Beyond the Static Caliper: Dynamical Translocases and the Mathematical Imperative for Single-Molecule Proteomics.

Jaylen E Taylor, Parichit Sharma, Bryan A Krantz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jaylen E TaylorDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, U.S.A.
Parichit SharmaDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, U.S.A.
Bryan A KrantzDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, U.S.A.ORCID 0000-0002-4911-5824

Funding

Molecular mechanisms of anthrax toxin unfolding and translocationR21AI177237 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KRANTZ, BRYAN ANDREW · 2025 to 2025
$425k
NIAID NIH HHS R21 AI177237
6 · The paper itself

Abstract

The advent of single-molecule nanopore sequencing established a powerful platform for modern genomics by using static biological pores to report the translocation of canonical nucleic acids, enabling rapid, accessible nucleic acid analysis. However, extending this strategy to single-molecule proteomics has stalled against a fundamental biophysical bottleneck. Current efforts in nanopore proteomics attempt to retrofit these static, spatial "caliper" biological nanopores (e.g., α-hemolysin, MspA, CsgG, aerolysin) for protein sequencing despite the immense steric, charge, and conformational heterogeneity of proteins. Unlike the chemically uniform, polyanionic phosphodiester backbone of DNA, the proteome contains isosteric and isobaric variants that confound purely volumetric measurements made by static pores. To address this bottleneck, we propose the application of

Indexed as

aerolysinanthrax toxinMarkov kineticsnanopore sequencingPhysics-Informed Machine LearningSingle-molecule proteomicstranslocase

Identifiers

PMID42538970
PMCPMC13419519

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.