Evidence map›Paper›PMID 42538958›Full record

ArticlebioRxiv : the preprint server for biology2026

Hargobinder Kaur, Rebekah B Guevara, Yolanda Rivera-Cuevas, Einar B Olafsson, Joshua Mayoral, Leonardo Augusto, Alfredo J Guerra, Romir Patel, Kevin P Bohannon, Jonathan Z Sexton and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hargobinder KaurDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Rebekah B GuevaraDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America.
Yolanda Rivera-CuevasDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.ORCID 0000-0001-8389-5724
Einar B OlafssonDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Joshua MayoralDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America.
Leonardo AugustoDepartment of Pathology, and Microbiology, and Immunology, University of Nebraska Medical Center, Omaha, NE, USA.
Alfredo J GuerraDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.ORCID 0000-0001-8764-8413
Romir PatelDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Kevin P BohannonDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.ORCID 0000-0002-2097-8183
Jonathan Z SextonDepartment of Medicinal Chemistry, College of Pharmacy, Ann Arbor, Michigan, United States of America.
Phyllis I HansonDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
Louis M WeissDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, New York, United States of America.
Vern B CarruthersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.ORCID 0000-0001-6859-8895

Funding

Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
ANALYSIS OF ESCRT FUNCTION IN ENDOLYSOSOMAL TRAFFICKINGR01GM122434 · NIGMS · WASHINGTON UNIVERSITY · PI HANSON, PHYLLIS I · 2017 to 2024
$3.7M
AIDS associated Toxoplasma encephalitisR01AI194912 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI WEISS, LOUIS M. · 2025 to 2025
$2.5M
Composition and formation of the cyst wallR01AI134753 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2018 to 2022
$2.1M
Orbitrap Exploris 480 Basic SystemS10OD030286 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIDOLI, SIMONE · 2021 to 2021
$600k
Advanced Confocal Microscope in a multi-user facilityS10OD023591 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BAKER, NICHOLAS E · 2017 to 2017
$590k
Defining a novel protein network for Toxoplasma repurposing of host ESCRT machineryR21AI180278 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 2024 to 2025
$422k
Secreted effectors of Toxoplasma gondii bradyzoitesF31AI136401 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MAYORAL, JOSHUA ALEXANDER · 2018 to 2019
$83k
ESCRTing material to the invader: Mechanisms underlying Toxoplasma gondii endocytosis of host cytosolic proteinF31AI152297 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RIVERA-CUEVAS, YOLANDA · 2021 to 2021
$38k
NIAID NIH HHS F31 AI136401NIAID NIH HHS F31 AI152297NIAID NIH HHS R01 AI134753NIAID NIH HHS R01 AI194912NIAID NIH HHS R21 AI180278NIAID NIH HHS T32 AI007528NIAID NIH HHS T32 AI070117NIGMS NIH HHS R01 GM122434NIH HHS S10 OD023591NIH HHS S10 OD030286
6 · The paper itself

Abstract

The endosomal sorting complex required for transport (ESCRT) is a hetero-multimeric membrane-remodeling machinery essential for endosomal sorting, intraluminal vesicle formation, cytokinetic abscission, and membrane repair. ESCRT is also hijacked by some pathogens including the protozoan

Identifiers

PMID42538958
PMCPMC13419437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.