Evidence map›Paper›PMID 42538955›Full record

ArticlebioRxiv : the preprint server for biology2026

A domain-swapped proPC1/3 structure reveals a conformational checkpoint for ER export.

Pankaj Kumar, Phillip A Hyon, Rishi Nixon, Ashley V Bullington, Ciara A Payne, Iris Lindberg, Daniel L Kober

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pankaj KumarDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7025-5530
Phillip A HyonDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Rishi NixonDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
Ashley V BullingtonDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ciara A PayneDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Iris LindbergDepartment of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
Daniel L KoberDepartment of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-8657-9348

Funding

OneMP Mass PhotometerS10OD030312 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI BRAUTIGAM, CHAD · 2021 to 2021
$165k
NIH HHS S10 OD030312
6 · The paper itself

Abstract

Prohormone convertase 1/3 (PC1/3, encoded by

Indexed as

Cryo-EMglucose metabolismobesityPC1/3PCSK1post translational modificationsProhormone convertaseProhormone processingSecretory pathwaySerine proteasesZymogen maturation

Identifiers

PMID42538955
PMCPMC13419460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.