Evidence map›Paper›PMID 42538922›Full record

ArticlebioRxiv : the preprint server for biology2026

Microglia extract neuronal proteolytic organelles via skoupocytosis.

Renee Pepper, Jacqueline M Griswold, Frances Middleton-Davis, Sarah Syed, Yuuta Imoto, Lani Tran, Eunbin Park, Yu Kang T Xu, Dwight Bergles, JoAnn Buchanan and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Renee PepperDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jacqueline M GriswoldDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Frances Middleton-DavisDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sarah SyedDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Yuuta ImotoDepartment of Developmental Neurobiology, Division of Neuronal Cell Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Lani TranDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Eunbin ParkDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Yu Kang T XuSolomon H. Snyder Department of Neuroscience Johns Hopkins School of Medicine, Baltimore, MD, USA.
Dwight BerglesSolomon H. Snyder Department of Neuroscience Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7133-7378
JoAnn BuchananAllen Institute for Brain Science, Seattle, WA, USA.
Shigeki WatanabeDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7580-8141

Funding

Ultrafast membrane trafficking at synapsesR35NS132153 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Shigeki Watanabe · 2023 to 2026
$4.1M
CRCNS: Biophysical modeling of axonal morphology and functionR01MH139350 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Padmini Rangamani · 2024 to 2026
$1.1M
Dissecting a Novel Pathway for Degradative Endosome Generation during Rapid Synaptic Vesicle Recycling PathwayR35GM162501 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Yuuta Imoto · 2026 to 2026
$463k
NIGMS NIH HHS R35 GM162501NIMH NIH HHS R01 MH139350NINDS NIH HHS R35 NS132153
6 · The paper itself

Abstract

Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their soma for degradation where lysosomes are enriched, but some organelles are larger than these neuronal processes, questioning how these organelles are degraded. Here we show that microglia, the resident immune cells of the brain, extract proteolytic organelles from neurons both

Identifiers

PMID42538922
PMCPMC13419375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.