Evidence map›Paper›PMID 42538838›Full record

ArticleAnnals of medicine2026

Magnetic resonance imaging changes of thigh muscles in dermatomyositis patients with anti-Mi2 antibody.

Yikang Wang, Qingyue Yuan, Na Xu, Tuo Ji, Liguo Zhang, Feng Gao, Gaoyang Zhao, Haifeng Zhang, Hongliang Xu, Yun Yuan and 2 more

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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yikang WangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0002-6910-716X
Qingyue YuanDepartment of Neurology, Peking University First Hospital, Beijing, China.ORCID 0009-0009-6931-727X
Na XuHenan Institute of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou, China.
Tuo JiDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Liguo ZhangHenan Institute of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou, China.
Feng GaoHenan Institute of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou, China.
Gaoyang ZhaoDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Haifeng ZhangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Hongliang XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yun YuanDepartment of Neurology, Peking University First Hospital, Beijing, China.
Yajun LianDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Sen JiangDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0003-2668-3180

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnti-complex nucleosomal remodelling histone deacetylase (Mi2)-positive dermatomyositis (DM) is characterized by severe muscle damage. This study investigated muscle magnetic resonance imaging (MRI) features in anti-Mi2-positive DM, compared them with other DM subtypes, and evaluated their associations with clinical features.

methodsDM patients who underwent thigh MRI were enrolled, including 20 anti-Mi2-positive, 20 anti-TIF1γ-positive, 15 anti-NXP2-positive, and 19 anti-MDA5-positive cases. Clinical and imaging data were collected and compared across subtypes. The relationship between MRI features and clinical characteristics was analysed in the anti-Mi2-positive subgroup.

resultsAmong the four subtypes, anti-Mi2-positive DM had the highest myofascial oedema frequency in the sartorius and the lowest in the biceps femoris (both

conclusionThis study delineated baseline thigh MRI patterns in anti-Mi2-positive DM and demonstrated that baseline muscle oedema severity correlated with serological and clinical indicators of muscle damage. Additionally, findings from a small longitudinal cohort suggested a potential role for thigh MRI in assessing and monitoring muscle disease activity in this subtype, although these results are preliminary and require validation in larger studies.

Indexed as

AutoantibodiesDermatomyositisMi-2 Nucleosome Remodeling and Deacetylase ComplexMuscle, SkeletalAdultAgedEdemaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedThighAutoantibodiesMi-2 antibodiesMi-2 Nucleosome Remodeling and Deacetylase Complexanti-Mi2 antibodiesDermatomyositismagnetic resonance imaging

Identifiers

PMID42538838
PMCPMC13431018

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