Observational studyPain research & management2026
Dysregulated Pain-Autonomic Responses in Patients With Nonspecific Chronic Low Back Pain.
Observational study in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04433299 (Back Pain - Linking Phenotype to Pain Mechanism and Outcome.), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Back Pain - Linking Phenotype to Pain Mechanism and Outcome.
Who cites it
1 citing paper in PubMed.
- Dysregulated Pain-Autonomic Responses in Patients With Nonspecific Chronic Low Back Pain.Pain research & management · 2026Observational
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundNeurophysiological assessments might advance the understanding of nonspecific chronic low back pain (nsCLBP) by quantifying altered pain processing and associated autonomic responses. Contact heat-evoked potentials (CHEPs) and sympathetic skin responses (SSRs) were compared between nsCLBP patients and healthy controls (HCs), and their relationships with experimental and clinical pain ratings were explored.
methodsA total of 56 nsCLBP patients and 40 age- and sex-matched HCs were included in this study. All participants underwent simultaneous recordings of CHEPs and SSRs in response to two blocks of 15 heat stimuli applied at the back (i.e., the patients' clinical pain area) and the hand (nonpainful control area). Participants rated the perceived pain intensity of each contact heat stimulus using a numerical rating scale (0-10). The change of pain ratings, CHEP, and SSR amplitudes between blocks was calculated as habituation index.
resultsSSR latencies were prolonged in patients compared to HCs (F = 9.5, p = 0.003) and were shorter after back stimulation compared to hand stimulation (F = 9.6, p < 0.001). No other group differences were observed. Clinical pain intensities in patients correlated (1) with contact heat pain ratings in both areas (back: rho = 0.27, p = 0.041, control area: rho = 0.272, p = 0.042) and (2) inversely with CHEP P2 latencies after hand stimulation (current pain: rho = -0.324, p = 0.019; average 4 weeks: rho = -0.320, p = 0.022).
conclusionProlonged SSR latencies in nsCLBP might indicate a dysregulated pain-autonomic response.
trial registrationClinicaltrials.gov_identifier: NCT04433299.
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