Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus.

John R Pooley, Ali S Bienemann, Alison Young, Owen Hollings, Jiahui Wu, Eddie Mayo, Colin J Chu, Will G B Singleton

Abstract read

In one paragraph

Article in Fluids and barriers of the CNS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John R PooleyTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0000-0001-6773-5317

Ali S BienemannTranslational Biomedical Research Centre, Bristol Medical School, University of Bristol, Bristol, BS40 5DU, UK.

Alison YoungAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.

Owen HollingsTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.

Jiahui WuAcademic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.

Eddie MayoTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0009-0003-5251-8864

Colin J ChuTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK.ORCID 0000-0003-2088-8310

Will G B SingletonTranslational Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TD, UK. will.singleton@bristol.ac.uk.ORCID 0000-0001-8836-7613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using adeno-associated virus to transfer genetic information to the choroid plexus has emerged as a promising route for long-term gene therapy in the brain for a variety of conditions. Overexpression of proteins has proved effective in small animal models but few attempts have been made to translate this technology to clinic, suppress the activity of a protein of interest, or further expand the limited capsid serotypes known to have choroid plexus tropism. We utilise transfer of green fluorescent protein to show choroid plexus epithelium tropism for novel AAV6 derived capsid ShH10

Indexed as

Choroid PlexusDependovirusTransgenesAnimalsGenetic VectorsGreen Fluorescent ProteinsInjections, IntraventricularMaleMiceRatsRats, Sprague-DawleySwineTransduction, GeneticGreen Fluorescent ProteinsAAVAquaporinChoroid plexusCRISPRDistributionGene therapyIntracerebroventricularKnockdownSaCas9ShH10

Identifiers

PMID42538560

DOI10.1186/s12987-026-00831-4

PMCPMC13428447

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.