ArticleNeurocritical care2026
Estimation of Intracranial Elasticity and Venous Outflow Resistance from Arterial Pressure and ICP Waveforms in Severe Brain Injury.
Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
3 authors.
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Abstract
introductionThe intracranial pressure (ICP) waveform conveys important information regarding the state of intracranial physiology, but in clinical practice it is typically analyzed in a qualitative fashion. We sought to develop a minimized model of intracranial physiology that describes intracranial dynamics occurring in a single cardiac cycle. By using an abridged model to which inputs of measured arterial and ICP waveforms from patients with brain injury can be applied, we aimed to derive estimates of intracranial elastance and venous outflow resistance.
methodsThe minimized model has two capacitor elements, representing arterial wall and intracranial compliance, and two resistance elements, representing intracranial viscoelasticity and venous outflow resistance. We use a parameter optimization method to achieve estimates of intracranial elastance and venous outflow resistance. We studied patients with brain injury in the neurointensive care unit who underwent ICP monitoring and analyzed data from periods of normal and elevated ICP.
resultsWe studied 375 ICP waveforms in 15 patients. Model-derived waveforms corresponded closely to measured ICP waveforms at both normal and elevated ICP. Model-derived estimates of intracranial elastance and venous outflow resistance both increased significantly when ICP was elevated (mean increase of 1.0 mm Hg/mL and 0.9 mm Hg × s/mL, respectively).
conclusionsThe minimized model closely replicates measured ICP waveforms and allows for estimation of intracranial elastance and venous outflow resistance in patients with brain injury from readily available clinical parameters.
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