Evidence map›Paper›PMID 42538453›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Regional brain metabolism and metabolic connectivity alterations in corticobasal syndrome assessed with [

Matilde Nerattini, Andrea Leo, Valentina Bessi, Anna De Rosa, Giovanna De Michele, Valeria Gaudieri, Giulia Giacomucci, Alberto Cuocolo, Giuseppe De Michele, Valentina Berti and 1 more

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matilde NerattiniDepartment of Experimental and Clinical Biomedical Sciences, Nuclear Medicine Unit, University of Florence, Florence, Italy.
Andrea LeoDepartment of Experimental and Clinical Biomedical Sciences, Nuclear Medicine Unit, University of Florence, Florence, Italy.
Valentina BessiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Anna De RosaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
Giovanna De MicheleDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
Valeria GaudieriDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Giulia GiacomucciDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Alberto CuocoloDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Giuseppe De MicheleDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
Valentina BertiDepartment of Experimental and Clinical Biomedical Sciences, Nuclear Medicine Unit, University of Florence, Florence, Italy. valentina.berti@unifi.it.ORCID http://orcid.org/0000-0001-9947-6559
Sabina PappatàIRCCS SYNLAB SDN, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCorticobasal syndrome (CBS) is a clinically defined phenotype with different underlying neuropathological substrates most commonly the 4-repeat tauopathy corticobasal degeneration (CBD). 2-[

methodsThirty-nine CBS patients underwent [

resultsCBS patients showed asymmetric hypometabolism predominantly in frontal, parietal, and temporal cortices, caudate and thalamus of the predominantly affected hemisphere, with additional contralateral involvement, notably in the cerebellum and caudate. Metabolic connectivity analyses revealed widespread intra- and inter-network disconnection, particularly involving frontal, parietal, and sensorimotor cortices, and thalamo-cortical pathways, with significant lateralization toward the affected hemisphere. Graph analysis showed decreased cortical node strength with relative increases in subcortical hubs and mixed changes in clustering coefficients, suggesting network reorganization.

conclusionThis first [

Indexed as

BrainCorticobasal DegenerationFluorodeoxyglucose F18Positron-Emission TomographyAgedFemaleHumansMaleMiddle AgedRadiopharmaceuticalsFluorodeoxyglucose F18RadiopharmaceuticalsBrain networksCorticobasal syndromeFDG-PETMetabolic connectivityNeurodegeneration

Identifiers

PMID42538453
PMCPMC13633311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.