Evidence map›Paper›PMID 42538450›Full record

ArticleJournal of cancer survivorship : research and practice2026

Multi-theory model-based exercise for cognition, physical fitness, and quality of life in patients with lymphoma during chemotherapy: a randomized controlled trial.

Yan Lin, Yabin Wang, Bingqian Ou, Guojuan Chen, Jianwei Zheng, Huimin Xiao, Yingchun Zeng

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Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Yan Lin *School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Yabin Wang *School of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Bingqian OuSchool of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Guojuan ChenSchool of Nursing, Fujian Medical University, Fuzhou, 350122, China.
Jianwei ZhengDepartment of Oncology, Fujian Medical University Union Hospital, Fuzhou, 350001, China. zjw10001@gmail.com.
Huimin XiaoSchool of Nursing, Fujian Medical University, Fuzhou, 350122, China. huimin_xiao@126.com.ORCID http://orcid.org/0000-0001-5468-301X
Yingchun ZengAlice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of a multi-theory model (MTM)-based exercise program on cognitive function, physical fitness, and quality of life among blood cancer survivors.

methodsIn this randomized controlled trial, 86 adults with lymphoma were recruited from a specialized oncology hospital in Fujian, southeastern China, and randomly assigned to an intervention or usual-care control group. The intervention group received an MTM-based exercise program plus usual care; controls received usual care alone. Outcomes were assessed at baseline (T0), immediately post-intervention (T1), and 4 weeks post-intervention (T2).

resultsOf 43 participants allocated to the intervention group, 38 completed the program (retention, 88.4%); mean adherence was 79.0%. Compared with usual care, the MTM-based exercise program significantly improved subjective cognitive function, physical fitness, and quality of life at T1 and T2 (all P < 0.001). Cognitive function improved from T0 to T1 (P < 0.001) and was maintained at T2, with no further significant change from T1 to T2 (P = 0.074). Physical fitness and quality of life improved from T0 to T1 and remained significantly higher at T2, compared with baseline (T0) (all P < 0.001).

conclusionsA MTM-based exercise program produced sustained short-term improvements in cognitive, physical, and quality-of-life outcomes among blood cancer survivors.

trial registrationChinese Clinical Trial Registry, registration number ChiCTR-2400083827. IMPLICATIONS FOR CANCER SURVIVORS: Theory-driven exercise may offer a feasible, behaviorally informed supportive-care strategy to protect brain health, preserve functional capacity, and enhance well-being across the blood cancer survivorship continuum.

Indexed as

Brain healthChemotherapy-related cognitive impairmentExercise interventionLymphomaMulti-theory model

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.