Targeting early pulmonary fibrosis with bone marrow mesenchymal stem cells and their derived exosomes: a comparative study of inhalation versus injection delivery in bleomycin-induced rat lung injury.

Meral Hakam, Ismail Mostafa, Eman I Hassanen, Hamdy Rizk, Marwa A Ibrahim, Ghada E Ali

Abstract read

In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Meral HakamDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Ismail MostafaDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Eman I HassanenDepartment of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.ORCID http://orcid.org/0000-0003-3670-6841

Hamdy RizkDepartment of Anatomy and Embryology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.ORCID http://orcid.org/0000-0001-6305-9913

Marwa A IbrahimDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. marwaibrahim@cu.edu.eg.ORCID http://orcid.org/0000-0001-7935-8379

Ghada E AliDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.ORCID http://orcid.org/0000-0002-4744-5264

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considering the increasing prevalence of pulmonary fibrosis (PF) and the increased exposure to risk factors contributing to its development, this study utilizes the bleomycin (BLM)-induced PF model to explore the potential early therapeutic strategies displayed by the bone marrow mesenchymal stem cells (BMMSCs) and their derived exosomes. The research assessed the efficacy of two administration methods: injection and inhalation by employing a comprehensive evaluation approach, including computed tomography imaging, biochemical assays, molecular analysis, and histopathological examinations. Fifty Wistar rats were divided into 5 groups; the CON group received saline intratracheally (IT) and served as the control group, the BLM group received IT BLM (5 mg/kg), the BMMSCs group received (BLM + BMMSCs in a dose of 10

Indexed as

Bleomycin-induced pulmonary fibrosisBone marrow mesenchymal stem cells (BMMSCs)Cell-free therapyExosomal bone marrow mesenchymal stem cells (Exo-BMMSCs)InhalationLung diseasesPulmonary fibrosis (PF)Regenerative medicine

Identifiers

PMID42538421

DOI10.1186/S13293-023-00542-7

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.