ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.
Grayson M Butcher, Erica M Ramirez, Christina M Ruiz, Erik Castillo, Mitchell R Farrell, Maricela X Martinez, Stephen V Mahler
Abstract read
In one paragraphArticle in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Erica M RamirezDepartment of Neurobiology and Behavior, Irvine Center for Addiction Neuroscience (ICAN), The University of California, Irvine, California 92697.
Erik CastilloDepartment of Neurobiology and Behavior, Irvine Center for Addiction Neuroscience (ICAN), The University of California, Irvine, California 92697.
Mitchell R FarrellDepartment of Neurobiology and Behavior, Irvine Center for Addiction Neuroscience (ICAN), The University of California, Irvine, California 92697.
Maricela X MartinezDepartment of Neurobiology and Behavior, Irvine Center for Addiction Neuroscience (ICAN), The University of California, Irvine, California 92697.
Stephen V MahlerDepartment of Neurobiology and Behavior, Irvine Center for Addiction Neuroscience (ICAN), The University of California, Irvine, California 92697 mahlers@uci.edu.ORCID https://orcid.org/0000-0002-8698-0905 Funding
Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine M Gall · 2018 to 2026
$18.2MDynamic epigenomic landscape of opioid abuse following early-life adversityU01DA053826 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, CHRISTIE D FOWLER · 2022 to 2026
$3.4MVentral Pallidum Circuits Underlying Preclinical Models of Opioid AddictionR01DA055849 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2023 to 2026
$1.4MOn circuit mechanisms of reward behaviors after early-life adversityR01MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2023 to 2024
$1.3MPersistent Impacts of Adolescent THC on Microglial Function and Opioid Addiction RiskF99NS141399 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARTINEZ, MARICELA XOCHIL · 2024 to 2025
$94kNIDA NIH HHS P50 DA044118NIDA NIH HHS R01 DA055849NIDA NIH HHS U01 DA053826NIMH NIH HHS R01 MH132680NINDS NIH HHS F99 NS141399
6 · The paper itselfAbstract
Addiction is a heterogeneous disorder, and the specific psychological processes and neural mechanisms involved are hard to parse in humans. However, animal models allow the biological substrates of addiction-relevant behaviors to be examined one at a time. Ventral pallidum GABAergic neurons (VP
Indexed as
Analgesics, OpioidBasal ForebrainGABAergic NeuronsRewardAnimalsDrug-Seeking BehaviorHeroinMaleMotivationRatsRats, TransgenicRemifentanilAnalgesics, OpioidHeroinRemifentaniladdictionbehaviorcueseffortheroinremifentanilreward
Identifiers
PMID42538301
PMCPMC13519650
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