Evidence map›Paper›PMID 42538287›Full record

ArticleGenes & development2026

Systematic identification of germ granule proteins reveals specialized roles in RNAi and small RNA inheritance.

Shihui Chen, Lucas H Prescott, Craig C Mello, Carolyn M Phillips

Abstract read
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Shihui ChenDepartment of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA.ORCID http://orcid.org/0009-0006-3036-5475
Lucas H PrescottRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.ORCID http://orcid.org/0000-0002-9273-0128
Craig C MelloRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, 01605, USA.ORCID http://orcid.org/0000-0001-9176-6551
Carolyn M PhillipsDepartment of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA; cphil@usc.edu.ORCID http://orcid.org/0000-0002-6228-6468

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Regulation of gene expression and genome organization by small RNAsR35GM119656 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Carolyn Marie Phillips · 2016 to 2026
$5.3M
RNA MEDIATED GENETIC INTERFERENCE IN C ELEGANSR01GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 1999 to 2014
$4.6M
RNA Mediated Genetic Interference in C. elegansR37GM058800 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MELLO, CRAIG C · 2015 to 2024
$3.7M
Investigation of RNA interference and related gene regulatory mechanismsR35GM153442 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG C MELLO · 2024 to 2026
$1.0M
NCI NIH HHS P30 CA014089NIGMS NIH HHS R01 GM058800NIGMS NIH HHS R35 GM119656NIGMS NIH HHS R35 GM153442NIGMS NIH HHS R37 GM058800NIH HHS P40 OD010440
6 · The paper itself

Abstract

Biomolecular condensates, such as germ granules, organize RNAi pathways critical for fertility and genome regulation. However, the protein composition and functional contributions of these condensates remain poorly defined. Here, we applied TurboID proximity labeling to the

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsGerm CellsInheritance PatternsRNA InterferenceRNA, Small InterferingAnimalsArgonaute ProteinsMutationPiwi-Interacting RNAArgonaute ProteinsCaenorhabditis elegans ProteinsPiwi-Interacting RNAPRG-1 protein, C elegansRNA, Small Interferingfertilitygerm granulepiRNA pathwayPIWIRNAiRNA inheritance

Identifiers

PMID42538287
PMCPMC13599730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.