Evidence map›Paper›PMID 42537603›Full record

ArticleParkinsonism & related disorders2026

Retinal neurovascular signatures in response to 6-month yoga exercise in patients with Parkinson's Disease.

Andrew Hoover, Amanda Virgets, Kylie J Martinez, Bonnie Levin, Byron L Lam, Ihtsham Haq, Fabiana Navia, Joseph F Signorile, Jianhua Wang, Hong Jiang

Abstract read
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In one paragraph

Article in Parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Andrew HooverDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Duke University School of Medicine, Durham, NC, USA.
Amanda VirgetsDepartment of Kinesiology and Sports Sciences, University of Miami, FL, USA.
Kylie J MartinezDepartment of Kinesiology and Sports Sciences, University of Miami, FL, USA.
Bonnie LevinDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Byron L LamDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Ihtsham HaqDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Fabiana NaviaDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Joseph F SignorileDepartment of Kinesiology and Sports Sciences, University of Miami, FL, USA.
Jianhua WangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Hong JiangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: h.jiang@med.miami.edu.

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Victor L Perez · 2004 to 2026
$12.2M
Novel Biomarkers of Small Vessel Contributions to Vascular Cognitive Impairment and Dementia (VCID)R01NS111115 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A, WANG, JIANHUA · 2019 to 2023
$3.7M
NEI NIH HHS P30 EY014801NINDS NIH HHS R01 NS111115
6 · The paper itself

Abstract

purposeTo characterize retinal neurovascular signatures in response to a 24-week yoga intervention in patients with Parkinson's disease (PD).

methodsSeventeen patients with PD (mean age: 71.4 ± 6.7 years; 8 females) were enrolled and participated in three 1-h yoga sessions per week for 24 consecutive weeks. Retinal neurovascular parameters were assessed at baseline and at 6-month follow-up. Retinal blood flow (RBF) was measured using a Retinal Function Imager. Retinal vessel density (RVD), retinal vessel length density (RVLD), and retinal tissue volume (RTV) were assessed using optical coherence tomography angiography (OCTA). Retinal capillary function (RCF) and retinal tissue perfusion (RTP) were calculated based on these variables.

resultsRBF significantly increased following 6 months of yoga training (P = 0.049). Changes in RVD were significantly correlated with disease duration (r = -0.67; P = 0.007) and Hoehn and Yahr (H&Y) stage (r = -0.77; P < 0.001). Patients with disease duration <5 years demonstrated greater improvements in RVD compared with those whose duration was ≥5 years (P = 0.004). Similarly, patients at H&Y stage 1 exhibited greater RVD improvements compared to those at H&Y stage ≥2 (P = 0.002).

conclusionThis study is the first to investigate retinal neurovascular responses to yoga training in patients with PD. While RBF marginally increased, RVD exhibited disease-severity and duration-dependent variations, suggesting RBF and RVD are potential biomarkers for monitoring disease progression and the efficacy of aerobic interventions such as yoga in PD.

Indexed as

Parkinson DiseaseRetinaRetinal VesselsYogaAgedFemaleHumansMaleMiddle AgedRegional Blood FlowTomography, Optical CoherenceExerciseParkinson's DiseaseRetinal blood flowRetinal tissue volumeRetinal vascular densityYoga

Identifiers

PMID42537603
PMCPMC13489793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.