ArticleJournal of neurophysiology2026
Sympathetic long-term facilitation following acute intermittent hypoxia is similar in the diurnal rest versus active phase in vagal-intact rats.
Article in Journal of neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acute intermittent hypoxia (AIH) elicits long-lasting increases in phrenic and sympathetic nerve activity, effects known as phrenic (pLTF) and sympathetic long-term facilitation (sympLTF), respectively. In anesthetized, paralyzed, vagotomized, and ventilated rats, pLTF magnitude following AIH consisting of 15, 1-min isocapnic hypoxic episodes (i.e., 15x1) is greater during the mid-rest versus mid-active phase of the diurnal cycle. However, it is unknown if sympLTF exhibits similar diurnal regulation. In urethane-anesthetized, mechanically ventilated, male Sprague-Dawley rats, we hypothesized that sympLTF elicited by 15x1 AIH ([Formula: see text] 40-55 mmHg) is greater in the mid-rest than in mid-active diurnal phase. We report renal sympathetic nerve activity (RSNA) remained elevated 90 min post-AIH, with similar responses in mid-rest (
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