Evidence map›Paper›PMID 42536751›Full record

ArticleScience advances2026

Transient receptor potential vanilloid 2 functions as a directional driver for hepoxilin A

Claudia Feriotti, Regino Mercado-Lubo, Merran Bryford, Rebecca Ferrisi, Francesca Gado, Clementina Manera, Keyi Liu, Ping Lu, Yushuan Lai, Beth A McCormick and 1 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Claudia FeriottiDepartment of Life Sciences, Center for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0002-5184-5359
Regino Mercado-LuboDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Merran BryfordDepartment of Life Sciences, Center for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Rebecca FerrisiDipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0001-9709-766X
Francesca GadoDipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0003-2971-0834
Clementina ManeraDipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-7379-5743
Keyi LiuDipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Ping LuDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Yushuan LaiDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0009-0000-4111-2023
Beth A McCormickDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Randall MrsnyDepartment of Life Sciences, Center for Therapeutic Innovation, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0001-8505-8516

Funding

Control of Neutrophilic Inflammation in Intestinal Health and DiseaseR01DK109677 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Beth A McCormick · 2016 to 2026
$5.2M
Intestinal Homeostasis Induced by CommensalsR01DK125407 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCCORMICK, BETH A · 2020 to 2023
$2.2M
NIDDK NIH HHS R01 DK109677NIDDK NIH HHS R01 DK125407
6 · The paper itself

Abstract

Neutrophil migration involves a dynamic balance of chemoattractant and inhibitory signals. We previously identified hepoxilin A

Indexed as

Cell MovementNeutrophilsTRPV Cation ChannelsAnimalsCell MembraneEndocannabinoidsHumansReceptor, Cannabinoid, CB2EndocannabinoidsReceptor, Cannabinoid, CB2TRPV2 protein, humanTRPV Cation Channels

Identifiers

PMID42536751
PMCPMC13426407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.