Evidence map›Paper›PMID 42536749›Full record

ArticleScience advances2026

ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism.

Maeva Loock, Blandine Lucchini, Emmanuelle Latour, Margot Tissandier, Marie Lhomme, Maharajah Ponnaiah, Lucie Hernandez, Loic Maillard, Jean Soulier, Olivier Bluteau and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Maeva LoockUniversité Paris-Saclay, Gustave Roussy, CNRS UMR9019, F-94805, Villejuif, France.ORCID 0000-0002-4957-2814
Blandine LucchiniUniversité Paris-Saclay, Gustave Roussy, INSERM U1360, F-94805, Villejuif, France.ORCID 0009-0006-7178-6807
Emmanuelle LatourINSERM U1342, Institut de la Leucémie Paris Saint-Louis, Université Paris-Cité, Paris, France.
Margot TissandierUniversité Paris-Saclay, Gustave Roussy, CNRS UMR9019, F-94805, Villejuif, France.
Marie LhommeIHU-ICAN, Foundation for Innovation in Cardiometabolism and Nutrition, Paris, France.ORCID 0000-0002-6335-4506
Maharajah PonnaiahIHU-ICAN, Foundation for Innovation in Cardiometabolism and Nutrition, Paris, France.ORCID 0000-0001-7761-4228
Lucie HernandezUniversité Paris Cité, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342/CNRS EMR8000, Paris, France.
Loic MaillardUniversité Paris Cité, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342/CNRS EMR8000, Paris, France.
Jean SoulierUniversité Paris Cité, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342/CNRS EMR8000, Paris, France.
Olivier BluteauService de Biochimie Endocrinienne et Oncologique, Assistance publique - Hôpitaux de Paris Sorbonne Université Pitié Salpêtrière, Paris, France.ORCID 0000-0002-6943-8858
Camille LobryINSERM U1342, Institut de la Leucémie Paris Saint-Louis, Université Paris-Cité, Paris, France.ORCID 0000-0003-0550-4921
Marie-Laure ArcangeliUniversité Paris-Saclay, Gustave Roussy, INSERM U1360, F-94805, Villejuif, France.ORCID 0000-0002-1726-1472
Wilfried Le GoffIHU-ICAN, Foundation for Innovation in Cardiometabolism and Nutrition, Paris, France.ORCID 0000-0002-7611-9644
Dominique BluteauUniversité Paris-Saclay, Gustave Roussy, CNRS UMR9019, F-94805, Villejuif, France.ORCID 0000-0002-6530-2363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fanconi anemia (FA) is characterized by defective DNA repair and chronic p53 activation, predisposing to acute myeloid leukemia through persistent genomic instability. The molecular adaptations enabling cell survival under chronic stress remain poorly understood. This study investigates the role of ZMAT3, a p53 responsive RNA binding protein overexpressed in FA deficient cells, to elucidate its role in cellular adaptation. Using FA patient fibroblasts and

Indexed as

Fanconi AnemiaSphingolipidsAcid CeramidaseAnimalsCell DeathCeramidesDNA DamageFerroptosisFibroblastsHumansMiceMice, KnockoutAcid CeramidaseASAH1 protein, humanCeramidesSphingolipids

Identifiers

PMID42536749
PMCPMC13426403

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.