Evidence map›Paper›PMID 42536730›Full record

ArticleScience advances2026

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.

Eliona Tsefou, Sumi Bez, Timothy J Y Birkle, Martha Foiani, Naoto Watamura, Mathieu Bourdenx, Daria Gavriouchkina, Emir Turkes, Samuel Crawford, Rachel Coneys and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eliona TsefouUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-4643-2584
Sumi BezUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-8971-5103
Timothy J Y BirkleUK Dementia Research Institute, University College London, London, UK.
Martha FoianiUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0003-4157-2606
Naoto WatamuraUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0001-7971-7378
Mathieu BourdenxUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-9799-9222
Daria GavriouchkinaUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-7488-5898
Emir TurkesUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-7447-1476
Samuel CrawfordDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.ORCID 0009-0003-7017-4583
Rachel ConeysUK Dementia Research Institute, University College London, London, UK.
Adrian M IsaacsUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-6820-5534
Karen E DuffUK Dementia Research Institute, University College London, London, UK.ORCID 0000-0002-6177-868X

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
NIA NIH HHS P30 AG062677NIA NIH HHS U19 AG063911
6 · The paper itself

Abstract

The accumulation of pathological four-repeat (4R) tau is central to several frontotemporal dementia (FTD) subtypes, but human neuronal models amenable to high-throughput screening of 4R tau-targeting therapies remain very limited. To address this, we developed induced pluripotent stem cell (iPSC)-derived i

Indexed as

NeuronsTauopathiestau ProteinsHumansInduced Pluripotent Stem CellsMutationMAPT protein, humantau Proteins

Identifiers

PMID42536730
PMCPMC13426404

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.