Evidence map›Paper›PMID 42536729›Full record

ArticleScience advances2026

sPLA

Shunya Nakayama, Akane Kanamori, Takeshi Kamakura, Kosuke Kamiya, Kai Kudo, Ryo Yanagiya, Takanobu Shimizu, Yoshimi Miki, Yuki Nagasaki, Masaya Araki and 11 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Shunya NakayamaDepartment of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0001-9664-609X
Akane KanamoriDepartment of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0009-0005-6171-9363
Takeshi KamakuraDepartment of Regulation of Infectious Cancer, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka, Japan.ORCID 0009-0002-4523-8971
Kosuke KamiyaDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0009-0002-8437-6146
Kai KudoDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-5410-3334
Ryo YanagiyaDepartment of Hematology and Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-2092-8194
Takanobu ShimizuDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0003-1186-0703
Yoshimi MikiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-8587-0333
Yuki NagasakiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4717-6877
Masaya ArakiDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0009-0004-4376-4278
Koichiro TateishiDepartment of Virology, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0001-5964-4140
Yoko ItoDivision of Pulmonary Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-7791-1967
Yoshiki ShiraishiDivision of Pulmonary Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0001-5275-6318
Yasushi NakamotoDepartment of Innovative Medical Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0009-0008-6546-2448
Hiroyuki HosokawaDepartment of Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-9592-2889
Yumi MatsuzakiDepartment of Life Science, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.ORCID 0000-0002-3729-2997
Hitoshi ShimanoDepartment of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.ORCID 0000-0002-5562-5572
Koichiro AsanoDivision of Pulmonary Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-9044-3061
Norio YamamotoDepartment of Virology, Division of Host Defense Mechanism, Tokai University School of Medicine, Isehara, Kanagawa, Japan.ORCID 0000-0002-5574-1960
Makoto MurakamiLaboratory of Microenvironmental Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4565-6017
Ai KotaniDepartment of Regulation of Infectious Cancer, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because cytokine storm syndromes such as sepsis, acute respiratory distress syndrome (ARDS), and coagulopathy, including those seen in COVID-19, are fatal, development of highly effective therapeutics is urgently needed. Recent evidence suggests that the hydrolysis of phospholipids in extracellular vesicles (EVs) by secreted phospholipase A

Indexed as

Cytokine Release SyndromeExtracellular VesiclesPhospholipases A2, SecretoryAnimalsCOVID-19HumansMembrane FluidityPhospholipidsSARS-CoV-2Phospholipases A2, SecretoryPhospholipids

Identifiers

PMID42536729
PMCPMC13426417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.