Evidence map›Paper›PMID 42536725›Full record

ArticleScience advances2026

Programming angiogenesis with tunable assemblies of multifunctional peptides.

Joseph Dodd-O, Bobak Shadpoor, Abhishek Roy, Roya Jafari, Tarunya R Sudarshan, Abigail Holberton, Dongjing He, Francesco Coppola, Daniel M Dinakarapandian, Deep Malu and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Joseph Dodd-ODepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0009-0009-2917-9896
Bobak ShadpoorDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0009-0005-7132-2060
Abhishek RoyDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0009-0005-9927-2544
Roya JafariDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0009-0009-0093-4085
Tarunya R SudarshanSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Abigail HolbertonGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.ORCID 0009-0004-6719-8426
Dongjing HeSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0003-1034-4256
Francesco CoppolaDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2429-204X
Daniel M DinakarapandianSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0009-0000-0081-3958
Deep MaluSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-8681-0957
Gelavizh GharatiDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Alexandra GriffithDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.ORCID 0009-0006-8288-025X
Harrison Rohe-WeinerDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.ORCID 0009-0004-4833-5675
Siya PatelDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Edward BonderDepartment of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.ORCID 0000-0001-6463-9143
Yuhang HuSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-2274-4903
Levi WoodGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332 USA.ORCID 0000-0002-4248-0888
Anant K ParavastuSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0001-7183-1942
Petr KralDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0003-2992-9027
Vivek A KumarDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.ORCID 0000-0001-7536-9281

Funding

Diversity Supplement for Angiogenic and anti-microbial supports for pulp regenerationR01DE031812 · NIDCR · UNIVERSITY OF HOUSTON · PI Vivek Kumar · 2022 to 2026
$3.3M
Characterizing Alzheimer's Amyloid-beta Oligomer Structures by Solid-State NMR and Cryo-Electron MicroscopyRF1AG073434 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PARAVASTU, ANANT KRISHNA, ROSENBERRY, TERRONE L · 2022 to 2022
$1.6M
VECTor/CT/OI Multimodal Imaging for Biomedical ResearchS10OD026875 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI HOWELL, ROGER W. · 2020 to 2020
$1.4M
NIA NIH HHS RF1 AG073434NIDCR NIH HHS R01 DE031812NIH HHS S10 OD026875
6 · The paper itself

Abstract

Therapeutic angiogenesis is constrained by the inability to localize, sustain, and finely tune vascular signaling. Here, we detail a supramolecular peptide system that enables angiogenic programming by decoupling mechanical integrity from receptor-level bioactivity. We integrate a vascular endothelial growth factor (VEGF)-mimetic amphiphile (SLan) with a mechanically robust β sheet peptide (K1) to yield injectable nanofiber hydrogels with tunable stiffness (100 to 1000 pascals) and preserved vascular endothelial growth factor receptor 2 (VEGFR2) affinity. Molecular dynamics simulations and solid-state nuclear magnetic resonance revealed that the coassembly mitigates steric interference between domains, enabling dense supramolecular packing while maintaining optimal receptor accessibility. The resulting SLan-K1 formulation preserves the secondary structure, activating canonical VEGFR2-MEK (mitogen-activated protein kinase kinase)-ERK (extracellular signal-regulated kinase). In vitro, these hydrogels induce endothelial proliferation; in vivo, they drive rapid neovascular infiltration and stable vascular integration in murine and rodent implants. This design unites peptide self-assembly, receptor binding kinetics, and immunophenotypic outcomes in defining a molecular framework for tunable angiogenic materials. This strategy establishes a modular platform for engineering instructive microenvironments that bridge molecular design and tissue-scale functionality.

Indexed as

AngiogenesisNeovascularization, PhysiologicPeptidesAnimalsCell ProliferationHumansHuman Umbilical Vein Endothelial CellsHydrogelsMiceMolecular Dynamics SimulationVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2HydrogelsPeptidesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2

Identifiers

PMID42536725
PMCPMC13426406

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.