Evidence map›Paper›PMID 42536722›Full record

ArticleScience advances2026

Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice.

Qing-Long Miao, James Okoh, Ahmet S Asan, Saifina Karedia, Jen Q Pan, Mauro Costa-Mattioli, Jeffrey L Noebels

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qing-Long MiaoBlue Bird Circle Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0008-1420-2363
James OkohDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Ahmet S AsanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Saifina KarediaBlue Bird Circle Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0002-3402-8530
Jen Q PanStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0003-0767-086X
Mauro Costa-MattioliDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Jeffrey L NoebelsBlue Bird Circle Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2887-0839

Funding

PLASTICITY IN DEVELOPING EPILEPTIC BRAINR01NS029709 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 1991 to 2025
$9.1M
Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleRF1MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2025 to 2025
$2.1M
Potentiate Cav3.3 To Treat Cognitive Deficits Associated with Impaired Sleep SpindleR01MH131719 · NIMH · BROAD INSTITUTE, INC. · PI PAN, JEN QIAN, WEÏWER, MICHEL · 2022 to 2023
$1.8M
NIMH NIH HHS R01 MH131719NIMH NIH HHS RF1 MH131719NINDS NIH HHS R01 NS029709
6 · The paper itself

Abstract

Childhood absence epilepsy (CAE) is a common genetic epilepsy with a frequently complex polygenic etiology, for which a genetically tractable animal model is lacking. Current anti-seizure medications fail to address the significant neurocognitive and social comorbidities of CAE, highlighting a critical unmet need for comprehensive therapies and a better understanding of the underlying mechanisms. To address this, we developed a digenic mouse model (

Indexed as

Epilepsy, AbsenceInterneuronsParvalbuminsSeizuresSocial BehaviorAnimalsCalcium Channels, T-TypeDisease Models, AnimalEthosuximideMaleMiceCalcium Channels, T-TypeEthosuximideParvalbumins

Identifiers

PMID42536722
PMCPMC13426438

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.