Evidence map›Paper›PMID 42536718›Full record

ArticleScience advances2026

PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcoma.

Blake R Wilde, Kyle D Klingbeil, Francesca Day, Chris Dann, Chris Frias, Manando Nakasaki, Sarah M Dry, Fritz C Eilber, Joseph G Crompton, David B Shackelford and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Blake R WildeDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8372-3954
Kyle D KlingbeilJonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Francesca DayDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0009-0004-7019-3300
Chris DannDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA.
Chris FriasDivision of Surgical Oncology, Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA.
Manando NakasakiDepartment of Pathology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Sarah M DryDepartment of Pathology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Fritz C EilberJonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3336-9333
Joseph G CromptonJonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9325-2909
David B ShackelfordJonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8270-898X
Brian E KaderaJonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5133-8656
Heather R ChristofkDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8662-4425

Funding

Nutrient Regulation of Cancer Cell GrowthR01CA215185 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Heather Christofk · 2018 to 2026
$4.3M
Metabolic Control of Hair Follicle Stem Cell Homeostasis and TumorigenesisR01AR070245 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTOFK, HEATHER, LOWRY, WILLIAM E · 2018 to 2022
$2.1M
NCI NIH HHS R01 CA215185NIAMS NIH HHS R01 AR070245
6 · The paper itself

Abstract

Well-differentiated and dedifferentiated liposarcoma (WD/DD LPS) represent a pathological continuum, often coexisting within the same tumor. While the dedifferentiated component is clinically aggressive, marked by rapid growth and metastatic potential, the evolutionary relationship between WD and DD LPS remains unknown. To investigate this, we performed single-nucleus RNA sequencing on matched WD and DD tumor regions. Both compartments shared a predominant population of undifferentiated mesenchymal cells, but only WD regions contained cells expressing adipocytic differentiation markers and PPARG target genes. Given the central role of PPARG in coordinating lipid metabolism during adipogenesis, these findings suggest that loss of this program may underlie the poorly differentiated, proliferative phenotype of DD LPS. Functional studies confirmed that PPARG activation in DD LPS cells induces lipid accumulation, reduces proliferation, and impairs tumor growth in vivo. These support a model in which impaired adipogenic differentiation underlies DD LPS pathology and identify PPARG as a potential therapeutic target to promote differentiation and suppress tumor progression.

Indexed as

AdipogenesisCell DifferentiationCell PlasticityLiposarcomaPPAR gammaAdipocytesAnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansLipid MetabolismMicePPAR gammaPPARG protein, human

Identifiers

PMID42536718
PMCPMC13426422

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.