ArticleScience immunology2026
Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages.
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In one paragraph
Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
20 authors.
Jichang HanDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7964-8701
Alexandre GallerandDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3127-1343
Rachel L MintzDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Jing ChenDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5998-6930
Feiya OuDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8289-4025
Shuai GaoDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3338-2431
Daniel D LeeDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1301-8501
Mandy M ChanDivision of Biology and Biomedical Sciences Graduate Program, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6511-0962
Michael T HarmonMedical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA.
Xue LinDivision of Infectious Disease, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0000-4085-2388
Bhama RamkhelawonDepartment of Surgery and Cell Biology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-9087-0995
Christopher G HuckstepDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0004-8066-6343
Michael R StricklandDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3899-5651
Tiantian LiuDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9377-9938
Kory J LavineDivision of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1948-9945
Joel D SchillingDivision of Cardiology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3884-1994
S Celeste MorleyDivision of Infectious Disease, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Bernd H ZinselmeyerDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-4172-6767
Kenneth M MurphyDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3505-9630
Gwendalyn J RandolphDivision of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9045-1195
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MThe protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2022 to 2026
$18.4MPRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6MSpatiotemporal checkpoints of macrophages in aortic aneurysms- RenewalR01HL146627 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Bhama Ramkhelawon · 2019 to 2026
$6.1MDifferentiation/migratory fate of monocyte-derived cellsR01AI049653 · NIAID · WASHINGTON UNIVERSITY · PI Gwendalyn J Randolph · 2000 to 2026
$4.6MDIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3MDefining the lymphatic basis of protein losing enteropathy after Fontan palliation or inflammatory gut diseaseDP1DK130660 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2021 to 2025
$3.8MMolecular Basis of cDC1 DevelopmentR01AI162643 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2025
$2.8MTranscriptional basis of embryonic macrophage developmentR21AI163421 · NIAID · WASHINGTON UNIVERSITY · PI MURPHY, KENNETH M · 2022 to 2023
$430kDeciphering the role of tumor-macrophage crosstalk during metastatic dissemination to the peritoneumK00CA264434 · NCI · WASHINGTON UNIVERSITY · PI HAN, JICHANG · 2022 to 2025
$388kDynamics and function of peritoneal myeloid cells during colorectal cancer peritoneal dissemination and implications for immunotherapyK99CA300889 · NCI · WASHINGTON UNIVERSITY · PI Jichang Han · 2025 to 2026
$334kMechanisms Underlying the Omental Support of Ovarian Cancer Peritoneal MetastasisF30CA281124 · NCI · WASHINGTON UNIVERSITY · PI Rachel Mintz · 2023 to 2026
$216kNCI NIH HHS F30 CA281124NCI NIH HHS F99 CA264434NCI NIH HHS K00 CA264434NCI NIH HHS K99 CA300889NHLBI NIH HHS F30 HL167565NHLBI NIH HHS R01 HL146627NHLBI NIH HHS T32 HL007081NIAID NIH HHS R01 AI049653NIAID NIH HHS R01 AI162643NIAID NIH HHS R21 AI163421NIAID NIH HHS R37 AI049653NIA NIH HHS P01 AG078106NIDDK NIH HHS DP1 DK130660NIDDK NIH HHS F32 DK145123NIDDK NIH HHS P30 DK052574
Abstract
Peritoneal cavity fluid and mesothelial surfaces host distinct resident macrophage populations, among which include the well-described Gata6
Indexed as
Cell DifferentiationMacrophages, PeritonealAnimalsEpitheliumGATA6 Transcription FactorMiceMice, Inbred C57BLGata6 protein, mouseGATA6 Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.