Evidence map›Paper›PMID 42536591›Full record

ArticleMedicine2026

Association between the dietary index for gut microbiota and gallstone disease: A cross-sectional analysis considering the Dietary Inflammatory Index.

Wenwen Ni, Changqing Deng, Yijin Chen

Abstract read
In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Wenwen NiDepartment of General Surgery, Deqing People's Hospital (Deqing Campus, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University), Deqing, Zhejiang, China.
Changqing DengDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China.ORCID 0009-0006-4602-3226
Yijin ChenDepartment of Gastroenterology, Meizhou People's Hospital, Meizhou Academy of Medical Sciences, Meizhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dietary index for gut microbiota (DI-GM) reflects dietary patterns that may support or adversely affect gut microbial health. This study examined the association between DI-GM and prevalence of gallstone disease (GSD), while additionally exploring the potential mediating association of the Dietary Inflammatory Index (DII), using data from the National Health and Nutrition Examination Survey 2017-2020. This cross-sectional study analyzed 5669 adults from National Health and Nutrition Examination Survey 2017-2020. GSD status was defined by self-reported physician diagnosis. DI-GM scores were calculated from 14 dietary components categorized as beneficial or detrimental to gut microbiota. DII scores were derived from nutrient intake data. Associations were evaluated using multivariable logistic regression. Higher DI-GM scores were associated with a lower likelihood of GSD (adjusted odds ratio [OR] = 0.92, 95% confidence interval [CI]: 0.87-0.97, P = .004). Individuals with DI-GM ≥ 6 had significantly reduced GSD risk (adjusted OR = 0.71, 95% CI: 0.55-0.91, P = .007). The beneficial dietary component was inversely associated with GSD (adjusted OR = 0.93, 95% CI: 0.86-0.99, P = .047). No significant interactions were observed across subgroups. Mediation analysis showed an inverse association between DI-GM and DII, with a small but significant indirect association (approximately 28%). Higher DI-GM scores are associated with a lower prevalence of GSD. These findings suggest a potential role of dietary inflammatory in this association; however, given the simultaneous measurement of exposure, mediator, and outcome, the results should be interpreted with caution.

Indexed as

DietGallstonesGastrointestinal MicrobiomeInflammationAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrevalenceRisk Factorsdietdietary indexgallstone diseasegut microbiotaNHANES

Identifiers

PMID42536591
PMCPMC13433036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.