ArticleMedicine2026
Elevated inflammatory markers are associated with impaired bone health in patients with adult-onset Still's disease: A cross-sectional study.
Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult-onset Still's disease (AOSD) is a chronic systemic inflammatory disorder with sustained elevation of pro-inflammatory cytokines and frequent glucocorticoid use. Real-world data on bone health in AOSD remain scarce. This study aimed to evaluate bone health parameters and their associations with inflammatory markers in patients with AOSD. This cross-sectional study included 54 patients with AOSD who underwent dual-energy x-ray absorptiometry (DXA) at a tertiary referral center. Bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip, and trabecular bone score (TBS) were assessed. Associations between C-reactive protein (CRP), ferritin, cumulative glucocorticoid dose, and bone parameters were analyzed using Spearman correlation, partial correlation adjusted for age, sex, and body mass index (BMI), and multivariable logistic regression. The mean age was 58.2 ± 12.0 years (79.6% female). Osteoporosis and osteopenia were present in 40.7% and 38.9%, respectively. TBS assessment (n = 52) revealed that 38 patients (73.1%) had normal microarchitecture (TBS > 1.350) and 14 (26.9%) had partially degraded microarchitecture (TBS 1.200-1.350). CRP showed a significant negative correlation with TBS (r = -0.445, P = .001), which remained significant after Bonferroni correction (adjusted P = .019) and after partial correlation adjusting for age, sex, and BMI (r = -0.336, P = .015). In multivariable logistic regression adjusted for age, sex, and BMI, CRP was independently associated with osteoporosis (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.01-1.27, P = .039). In patients aged ≥ 50 years, log-transformed ferritin was independently associated with osteoporosis (OR 4.34, 95% CI 1.43-13.13, P = .009). Cumulative glucocorticoid dose was not significantly associated with bone parameters. These real-world data demonstrate a high burden of impaired bone health in patients with AOSD. CRP was independently associated with TBS and osteoporosis after adjustment for age, sex, and BMI, and ferritin was associated with osteoporosis in patients aged ≥50 years. These findings support the need for routine bone health screening in AOSD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.