ArticleJNCI cancer spectrum2026
Frailty and low utilization of curative-intent surgical resection in nonmetastatic pancreatic cancer.
Article in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundCurative-intent treatment for pancreatic ductal adenocarcinoma necessitates major surgery and chemotherapy, yet many patients do not undergo resection. Frailty may contribute to this phenomenon, but its prevalence and association with pancreatectomy in pancreatic ductal adenocarcinoma remains poorly defined. This study describes the distribution of frailty and its association with curative-intent surgery in a nationally representative cohort of patients with nonmetastatic pancreatic ductal adenocarcinoma.
methodsUsing Surveillance, Epidemiology, and End Results-Medicare data (2013-2019), we identified patients aged 66 years and older with nonmetastatic pancreatic ductal adenocarcinoma. Frailty was categorized as nonfrail, prefrail, mildly frail, or moderately to severely frail using the claims-based frailty index over the 12 months preceding diagnosis. We evaluated frailty distributions via kernel density estimation. We assessed the association between frailty category and receipt of surgery via logistic regression.
resultsAmong 8237 patients (mean age = 78 years, 57.6% female, 77.4% White race), 2486 (30.2%) underwent curative-intent pancreatectomy. Surgery was performed in 39.7% of nonfrail and 30.7% of prefrail patients; after adjustment, prefrail patients had similar odds of resection compared to nonfrail patients (adjusted odds ratio [OR] = 1.01, 95% confidence interval [CI] = 0.89 to 1.16). In contrast, 15.8% of mildly frail and 5.7% of moderately to severely frail patients underwent surgery; both groups had statistically significant lower odds of surgery vs nonfrail patients (mildly frail adjusted OR = 0.53, 95% CI = 0.43 to 0.66; moderately to severely frail adjusted OR = 0.18, 95% CI = 0.11 to 0.30).
conclusionsRemarkably, less than 40% of nonfrail patients with nonmetastatic pancreatic ductal adenocarcinoma underwent surgery, suggesting that curative-intent treatment remains infrequent even among lower-risk adults. Frailty is also common and strongly associated with decreased odds of surgical resection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.